Synthesis, characterization and application of mesoporous materials in the controlled release of ibuprofen

Abstract

Drug delivery systems consist of an active ingredient and a carrier system that can direct the release of the drug to the appropriate site and in the appropriate amount. The characteristics that these vehicles must meet are low toxicity, optimal properties for drug transport and release, and long half-life. Three mesoporous materials are reported in this work, the first one containing lattice aluminum; named Al-Si/SBA-3; the second one containing magnesium; named Mg-SBA-3, and the third one named LP-SBA-15. These materials were characterized by X-ray diffraction, resulting in hexagonal porous nanostructures, with lattice parameters of 3.63 nm for Al-Si/SBA-3 (without significant changes in the periodicity of the lattice). LP-SBA-15 is a novel large porous nanomaterial. It is encouraging the results of the application of these materials as host-transporters in the study of the modified release of Ibuprofen. LP-SBA-15 appears to be the most promising delivery system for IBU and its controlled release.