Browsing by Author "Giulianelli, Sebastián"

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    RXR expression in marine gastropods with different sensitivity to imposex development
    (Nature, 2020-06-11) Giulianelli, Sebastián; Primost, Mónica A.; Lanari, Claudia; Bigatti, Gregorio
    The superposition of male sexual characteristics in female marine gastropods (imposex) represents one of the clearest ecological examples of organotin-mediated endocrine disruption. Recent evidences suggest that signaling pathways mediated by members of the nuclear receptor superfamily, RXR and PPARγ, are involved in the development of this pseudohermaphroditic condition. Here, we identifed signifcant diferences in RXR expression in two caenogastropod species from Nuevo Gulf, Argentina, Buccinanops globulosus and Trophon geversianus, which present clear contrast in imposex incidence. In addition, B. globulosus males from a polluted and an unpolluted area showed diferences in RXR expression. Conversely, PPARγ levels were similar between both analyzed species. These fndings indicate specie-specifc RXR and PPARγ expression, suggesting a major role of RXR in the induction of imposex.