Effect of hydrothermal treatment on the materials MCM-41 type modified iron for drug delivery
Fecha
2016Autor
Cuello, Natalia
Elías, Verónica
Mendieta, Silvia
Longhi, María
Oliva, Marcos Iván
Crivello, Mónica
Eimer, Griselda Alejandra
Metadatos
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Synthesis of MCM-41 having magnetic elements embedded inside has been researched in
order to develop very interesting drug-delivery systems. In this work, MCM-41
nanostructured materials modified with iron were synthesized using the direct synthesis
method (DI) and a hydrothermal treatment (HT) was applied [1]. Due to that silanol groups
can form hydrogen bridge bonds with the carboxyl and carbonyl groups of indomethacin
(IN), the silanol groups density on the support was analyzed by IR spectroscopy. Then, the
drug was incorporated into both iron modified samples and into the pure MCM-41 and their
release profiles were evaluated "in vitro" using simulated body fluid as medium. All
modified materials have faster profiles than the pure silica matrix. This could be due to the
presence of nanospecies of oxides inside channels that might increase the steric diffusion
resistance. Thus, the drug could diffuse through the channels of the modified material with
less freedom that through those of MCM-41. However, the sample modified with iron by
this method with HT have a behavior similar to that of MCM-41 possibly due to the refiner
effect of HT on the nanospecies size. In addition, materials with HT have an increased
availability of silanol groups capable to interact with the indomethacin. This would explain
their high drug adsorption capacity and the slow drug release rate. Then, this solid have
good properties of adsorption and release, similar to that of the parent pure MCM-41 and
simultaneously their modification with iron nanospecies leads to materials with
superparamagnetic behavior.
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