Browsing by Author "Anunziata , Oscar Alfredo"

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    Controlled Release of Haloperidol from a novel SWCNT Nano composite coated with ZnO nanocrystals.
    (Univesidsad Tecnológica Nacional, 2023) Anunziata , Oscar Alfredo; Cussa, Jorgelina; Martínez , María Laura
    Starting from the physicochemical knowledge of the host properties of the na noscale systems would be applied to drug dosage [1,2]. We propose NM synthesis strategies that offer the necessary characteristics for these processes. First, we study the physicochemistry of the anchoring sites of the respective hosts (chemical bonds with reversible or irreversible adsorption) or physisorption (straightforward interactions). Then, whether to design carbon based nanomaterials (CNM), or nano engineered materials, containing the respective active sites (deposited or generated nanospecies), capable of interacting with the aforementioned hosts such as: redox sites, proton acceptor sites, electron donor-acceptor sites, to allow HOMO-LUMO chemical interactions that satisfy the needs of the process to be studied. The nanostructures that allow free diffusions and reversible adsorptions, dosage of molecules with applications in nanokinetics, etc., and determination of critical molecular sizes, calculated using experimental methods, and methods such as density functional theory and semiempirical methods, to avoid steric hindrances between molecules and 100 80 40 60 8 12 16 20 Experimental data Weibull Ritger-Peppas Higuchi Drug Released , % mol/w Time (h) 4 20 nanomaterials whether 2D or 3D, designing NMs with large surface area, physical, ther mal and chemical stability, and pore size, and adequate pore size. Advancing in this sense, this work studies the usage of: Haloperidol Release from ZnO nanocrystal Coated SWCNT, with 30nm of wide and 5 um of long, which by the effect of the interaction between the host and drug molecules and by diffusion through the porosity, leads to a substantial contribution to controlled drug release. The reduction in the dose and frequency of administration, possible improvement in the selectivity of the pharmacological activity, and a prolonged therapeutic effect. CNT prepared by sol gel method (using the same technique describe by us, [3]), but at different pH and long range of pristine mesoporous carbons material calcination, to obtain SWCNTs. The posterior deposition of ZnO, was obtained, employing ZnNO3, activated under N2 flow at 500ºC; offering adequate LUMO of Zn (the hybridized MO) for Haloperidol interactions. Haloperidol competitively blocks postsynaptic dopamine (D2) receptors in the meso limbic system of the brain, thereby eliminat ing dopamine neurotransmission and leading to antidelusionary and antihallucinagenic effects. Specifically, the dose of Haloperidol (potent antipsychotic drug), indicates that its release follows the so called "power law" or Weibull model, based on the results we obtained in our laboratory (Figure 1).
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    LP-SBA-15-TBA-CP: Tert-Butylamine and Cyclophosphamide detailed study by FTIR and 3D structure.
    (Univesidsad Tecnológica Nacional, 2023) Anunziata , Oscar Alfredo; Cussa, Jorgelina
    A careful study of the vibrational spectra of the host (LP-SBA-15), functionalizing agent, tert-Butylamine (TBA), and N, N-bis(2-chloroethyl)tetrahydro-2H-1,3,2- oxazaphosphorin-2-amine 2-oxide, cyclophosphamide (CP) was performed, as there is a diversity of assignments published by different authors [1-5]. Our preliminary OM studies (AM1, PM3, Density Functional Theory, application of the Fukui function), and extensive FTIR studies, we estimated the binding energies, bond lengths and bond angles of CP as well as for TBA-CP, leading us to suggest that CP is embedded in an ellipsoid.
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    Nanostructured SBA-15 host: synthesis, characterization and application in ketorolac-tromethamine release system.
    (Univesidsad Tecnológica Nacional, 2016) Cussa , jorgelina; Juárez , Juliana María; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Juárez , Juliana María
    The ordered mesoporous silica SBA-15 has been applied in studies of ketorolac tromethamine adsorption and release. The SBA-15 materials with hexagonal and regular structure were obtained using a triblock copolymer Pluronic P123 as template and TEOS as a silica source[1]. Drug delivery is an emerging field mainly focused on aiming drugs. The goal of this targeted delivery is to transport an amount of drugs to desirable sites (such as tumors and diseased tissues) while minimizing unwanted side effects of the drugs on other tissues [2]. Controlled drug delivery systems can achieve precise spatial and temporal delivery of therapeutic agents to the target site. Ketorolac tromethamine was adsorbed into SBA-15 silica nanochannels using ethanol as solvent. The physicochemical and textural properties of SBA-15 and ketorolac tromethamine/SBA-15 were characterized by X-ray diffraction, thermogravimetric analysis, transmission electron microscopy, Fourier transform infrared spectroscopy and BET surface studies. Drug release was evaluated by soaking the loaded silica mesoporous material into a solution of HCl (0.1N) at 37 ºC under continuous stirring. Release studies were performed in order to evaluate the required therapeutic efficacy. SBA-15 provides significant improvement in the controlled release of ketorolac tromethamine [3]. In this work, we have shown a promising drug storage material for the effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. SBA-15/KETO shows characteristic bands of both, drug materials and the inorganic framework. This indicates that KETO was adsorbed into SBA-15 channel surface without affecting the chemical structure or composition of KETO. The study also demonstrates the storage capacity and release properties of SBA-15 containing KETO. The release of KETO contained in SBA-15 can offer significant improve in controlled drug release and enhance a good analgesia effect.
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    Sulfated/Zr-containing mesoporous carbons: a promising nanostructured catalytic material.
    (Univesidsad Tecnológica Nacional, 2021) Anunziata , Oscar Alfredo; Martínez , María Laura
    In this work, we report the successful preparation of a promising material with acidic properties from starch-derived mesoporous carbon (SMC), functionalized with sulfated zirconia (SZr-SMC). The process of assembling P123, starch, zirconia, and silicon produces ordered mesoporous carbon modified with Zr. Reaction time and temperature are essential to avoid the appearance of poorly assembled or unsightly structures, reducing the surface area and the size of the pores. SZr SMC has a surface area of approximately 1300 m2/g, and a total pore volume of 0.94 cm3/g, composed mainly of mesoporous with an average pore size of 3.5 nm. The composition of the surface and the chemical states of the elements did not reveal ZrO2 as isolated clusters. Ammonia thermodesorption studies indicated that, SZr-SMC retains 2.49 mmol/g of NH3 at very high temperature, exhibiting a strong acidity. According to the data collected by infrared spectroscopy (FTIR), of pyridine desorbed at various temperatures, the total number of acidic sites was 2.36 mmol/g, and the distribution in weak- medium, strong, and super acidic sites was determined. The activity in the methylation of aniline and isopropanol dehydration indicated that the acid sites are strong, and have not redox properties. A new and promising catalyticmaterial based onmesoporous carbons modified with sulfated Zr is developed, which opens a wide range of acid-catalyzed reactions applied to industrial and medical processes.
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    Sulfur elimination by ODSwith titanium-modified SBA-16.
    (Univesidsad Tecnológica Nacional., 2015) Rivoira , Lorena Paola; Vallés , Verónica Alejandra; Ledesma , Brenda Cecilia; Martínez , María Laura; Anunziata , Oscar Alfredo; Beltramone, Andrea Raquel
    Over the past, oxidative desulfurization (ODS) has drawn considerable interest as a new alter-native method for deep sulfur elimination from light oils. This can be attributed to its attractive properties, including lower temperature and pressure conditions and lower operating cost than conventional hydrodesulfurization (HDS) process. Oxidation of organosulfur compounds results in the formation of sulfoxides/sulfones, highly polar and hence easily removed by both extraction into polar solvents or by adsorption. Due to their low reactivity, dibenzothiophene derivatives (DBTs) are the most refractory species to be eliminated from oils. Hence, the ODS process through which DBTs are converted to their corresponding sulfones involves great interest at present. In this work, we describe the preparation and characterization of new mesoporous catalytic materials based on Ti-containing SBA-16. We study here, the effect of the preparation method of titania-modified SBA-16 (characteristics of the active Ti and/or TiO2 species) and the effect of the different operation conditions in ODS of DBT under mild conditions in order to find the best performance. TiO2-modified mesoporous SBA-16 and titanium-substituted mesoporous SBA-16 were developed and tested in the oxidative desulfurization (ODS) of dibenzothiophene prevailing in liquid fuel. We assessed the impact exerted on performance of different reaction variables, including (nature and amount of the active catalytic species, phase system, molar ratio of oxidant H2O2 and DBT, reaction temperature, nature of the substrate and reuse of catalysts). We achieved 90% of S removal from a 0.2 wt.% dibenzothiophene solution at 60°C in less than 1 h of reaction. The best catalytic results are obtained with high exposed surface of nanometric TiO2 species of TiO2/SBA-16 sample. The activated catalyst is very active in ODS reaction and can be reused four times with no loss in activity