Nanostructured SBA-15 host: synthesis, characterization and application in ketorolac-tromethamine release system.
Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Univesidsad Tecnológica Nacional
Abstract
The ordered mesoporous silica SBA-15 has been applied in studies of ketorolac tromethamine
adsorption and release. The SBA-15 materials with hexagonal and regular structure were obtained
using a triblock copolymer Pluronic P123 as template and TEOS as a silica source[1].
Drug delivery is an emerging field mainly focused on aiming drugs. The goal of this targeted delivery
is to transport an amount of drugs to desirable sites (such as tumors and diseased tissues) while
minimizing unwanted side effects of the drugs on other tissues [2]. Controlled drug delivery systems
can achieve precise spatial and temporal delivery of therapeutic agents to the target site. Ketorolac
tromethamine was adsorbed into SBA-15 silica nanochannels using ethanol as solvent. The
physicochemical and textural properties of SBA-15 and ketorolac tromethamine/SBA-15 were
characterized by X-ray diffraction, thermogravimetric analysis, transmission electron microscopy, Fourier
transform infrared spectroscopy and BET surface studies. Drug release was evaluated by soaking the
loaded silica mesoporous material into a solution of HCl (0.1N) at 37 ºC under continuous stirring.
Release studies were performed in order to evaluate the required therapeutic efficacy. SBA-15
provides significant improvement in the controlled release of ketorolac tromethamine [3]. In this work,
we have shown a promising drug storage material for the effective encapsulation and controlled
release of KETO, achieving the required therapeutic efficacy. SBA-15/KETO shows characteristic bands
of both, drug materials and the inorganic framework. This indicates that KETO was adsorbed into
SBA-15 channel surface without affecting the chemical structure or composition of KETO. The study
also demonstrates the storage capacity and release properties of SBA-15 containing KETO. The release
of KETO contained in SBA-15 can offer significant improve in controlled drug release and enhance a
good analgesia effect.
Description
Keywords
SBA-15, Ketorolac tromethamine, Drug controlled release
Citation
XXV International Materials Research Congress.
Endorsement
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