Characterization of SARS-CoV-2 Dynamics in the Host

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dc.creatorAbuin, Pablo
dc.creatorAnderson, Alejandro
dc.creatorFerramosca, Antonio
dc.creatorHernandez - Vargas
dc.creatorGonzález, Alejandro
dc.date.accessioned2021-03-11T21:42:02Z
dc.date.available2021-03-11T21:42:02Z
dc.date.issued2020-06-01
dc.description.abstractWhile many epidemiological models were proposed to understand and handle COVID-19 pandemic, too little has been invested to understand human viral replication and the potential use of novel antivirals to tackle the infection. In this work, using a control theoretical approach, validated mathematical models of SARS-CoV-2 in humans are characterized. A complete analysis of the main dynamic characteristic is developed based on the reproduction number. The equilibrium regions of the system are fully characterized, and the stability of such regions is formally established. Mathematical analysis highlights critical conditions to decrease monotonically SARS-CoV-2 in the host, as such conditions are relevant to tailor future antiviral treatments. Simulation results show the aforementioned system characterization.es_ES
dc.description.affiliationFil: Abuin, Pablo. CONICET - Universidad Nacional del Litoral. Argentina.es_ES
dc.description.affiliationFil: Ferramosca, Antonio. CONICET - UTN Facultad Regional Reconquista. Argentina.es_ES
dc.description.affiliationFil: Hernandez - Vargas Esteban. Institute of Mathematics, UNAM, Mexico. Research Fellow, Frankfurt Institute for Advanced Studies. Germany.es_ES
dc.description.affiliationFil: Gonzales, Alejandro. CONICET - Universidad Nacional del Litoral. Argentina.es_ES
dc.description.affiliationFil: Anderson, Alejandro. CONICET - Universidad Nacional del Litoral. Argentina.es_ES
dc.description.peerreviewedPeer Reviewedes_ES
dc.formatapplication/pdfes_ES
dc.identifier.issn1367-5788
dc.identifier.urihttp://hdl.handle.net/20.500.12272/4873
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.useN/Aes_ES
dc.subjectEQUILIBRIUM SETS CHARACTERIZATION , IN-HOST MODEL , SARS-COV-2 INFECTION , STABILITY ANALYSIS , COVID-19es_ES
dc.titleCharacterization of SARS-CoV-2 Dynamics in the Hostes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versionpublisherVersiones_ES

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Producción Grupo de Investigación en Programación Electrónica y Control