Facultad Regional Córdoba
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Item Preparation, charactrization and mathematical modeling of keterolac reléase conteined in LP-SBA-15 host.(Universidad Tecnológica Nacional Regional Córdoba., 2017) Cussa , Jorgelina; Juárez , Juliana María; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Juárez , Juliana MaríaDrug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the LP-SBA-15 nanomaterial as a promising new host for drug delivery systems because of its high biocompatibility, in vivo biodegradability, and low toxicity. Ketorolac-LP-SBA-15 was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release, achieving the required therapeutic efficacy. The host shows ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, being the Ritger-Peppas model followed by the Weibull model the best ones. In this work, we show a promising drug storage material for effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. Studies indicate that KETO was adsorbed on the channel surface of LP-SBA-15 without affecting the structure or chemical composition of KETO. Controlled drug delivery systems can achieve precise delivery at the time and place of destination, keeping the concentration of the drug at points in the body within the optimal range and below the toxicity threshold. The study also demonstrates the storage capacity and release properties of LP SBA-15 containing KETO. The release of KETO contained in LP-SBA-15 can offer a significant improvement in the controlled release of the drug and the analgesic and anti-inflammatory effects, positively influenced, by the links formed between the host and drug molecules and by diffusion through the host porosity. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response.Item KETO/LP-SBA-15 Composite as a drug release system.(Universidad Tecnológica Nacional Regional Córdoba., 2017) Cussa , Jorgelina; Juárez , Juliana María; Prados, Antonela; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Juárez , Juliana MaríaControlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. SBA-15 with larger pore sizes material (LP-SBA-15) is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Large pore mesoporous silica supports has been applied in studies of ketorolac tromethamine (KETO) adsorption and release. KETO/LP-SBA-15 composite was synthesized. The material synthesis and loading of KETO into LP-SBA-15 pores were successful. We obtained promising results for controlled drug release using the novel LP-SBA-15 material. The ability of KETO/LP-SBA-15 release was measured. The concentration of KETO in HCl solution or buffer in a specific time was determined by UV-Vis. First-order, Higuchi and Ritger-Peppas (or Korsmeyer-Peppas) models were used to fit experimental release data. Figure 1 show the fitting results, where Qt/Q? is the release fraction per unit mass in time t, k represents release rate in all models and n is a measure of desorption intensity in Ritger-Peppas regression. In this work, we have shown a promising drug storage material for the effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. KETO was adsorbed into LP-SBA-15 channel surface without affecting the chemical structure or composition of KETO. The study also demonstrates the storage capacity and release properties of LP-SBA-15 containing KETO. The release of KETO contained in LP-SBA-15 can offer significant improve in controlled drug release and enhance a good analgesia effect.Item Ketorolac-trometamina/mcf: aplicación en sistemas de liberación de fármacos.(Universidad Tecnológica Nacional Regional Córdoba., 2018) Cussa , jorgelina; Juárez , Juliana María; Prados, Antonela; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Juárez , Juliana MaríaEn los últimos años, la atención se ha dirigido significativamente a la nanociencia y la nanotecnología. La administración de fármacos basados en nanomateriales se ha puesto en relieve por los investigadores académicos e industriales. Diversos materiales nanoestructurados se produjeron y se aplican a la administración de fármacos tales como nanopartículas, nanocápsulas, nanotubos, micelas, microemulsiones y liposomas (Wu et al., 2011). Los sistemas de liberación controlada de fármacos pueden lograr la entrega espacial y temporal precisa de agentes terapéuticos al sitio de destino. Generalmente, los sistemas de administración de fármacos controlada pueden mantener la concentración de fármacos en los sitios precisos del cuerpo dentro de la gama óptima y bajo el umbral de toxicidad, mejorar la eficacia terapéutica y reducir la toxicidad (Wang, 2009). Un sistema de administración de fármacos se puede definir como un sistema capaz de liberar un agente bioactivo portador en una ubicación específica a una velocidad específica. El objetivo principal de este tipo de sistema es la de facilitar la dosificación y la duración del efecto del fármaco, minimizando el daño al paciente y mejorar la salud humana, ya que permiten la reducción de la frecuencia de la dosis (Wang, 2009).Item LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release.(Universidad Tecnológica Nacional Regional Córdoba., 2023) Cussa, Jorgelina; Juárez , Juliana María; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Juárez , Juliana MaríaDrug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the nanomaterial LP-SBA-15 as an attractive new host for drug delivery systems due to its high biocompatibility, in vivo biodegradability, and low toxicity. LP-SBA-15/Ketorolac was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release and achieving the required therapeutic efficacy. The host shows the ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release from the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, the Ritger-Peppas model followed by the Weibull model the best ones. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid responseItem Novel preparation of CMK-3 nanostructured material modified with titania applied in hydrogen uptake and storage.(Universidad Tecnológica Nacional., 2017) Juárez , Juliana María; Ledesma , Brenda Cecilia; Gómez Costa, Marcos Bruno; Beltramone , Andrea Raquel; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Beltramone , Andrea Raquel; Ledesma , Brenda CeciliaThis work deals with the development of a novel procedure to synthesize titania-modified nano structured carbon employing Ti-SBA-15 as hard template. The new mesoporous carbon displays high specific surface area of 1044 m2/g and large pore volume of 0.7 cm3/g. XRD pattern of Ti-CMK-3 indicates that the ordered structure of this material is similar to the CMK-3. XRD, XPS and UVeVis-DRS analysis indicated that Ti is highly dispersed as anatase phase in Ti-CMK-3. The synthesized Ti-CMK-3 exhibited significantly enhanced H2 storage properties (2.6 wt%, equivalent to 13 mmol/g) compared with CMK-3 without Ti (2.2 wt%, 11 mmol/g) at 77 K and 10 bar.Item Reservorio nanoscópico de hidrógeno a partir de biorresiduos de casacara de naranjas.(Universidad Tecnológica Nacional., 2022) Juárez , Juliana María; Ledesma , Brenda Cecilia; Anunziata , Oscar Alfredo; Gómez Costas , Marcos Bruno; Beltramone, Andrea Raquel; Beltramone, Andrea Raquel; Anunziata , Oscar Alfredo; Ledesma , Brenda CeciliaEste trabajo aborda el enfoque de valorización de biorresiduos para el desarrollo de un novedoso nanomaterial carbonoso para ser utilizado en la adsorción de hidrógeno como una alternativa en el uso de hidrógeno verde. En esta investigación, los carbones activados se sintetizaron a partir de cáscara de naranja utilizando diferentes condiciones de síntesis. Con los carbones activados obtenidos con la mejor estructura y textura se estudió la adsorción de hidrógeno y los efectos en la meso/microporosidad de estos. La activación del carbón se realizó mediante un proceso químico con ácido fosfórico como agente activador, variando la concentración de ácido, la relación sustrato / agente activador y el tiempo de contacto entre ellos. El mejor material se obtuvo utilizando tiempo de carbonización de 1 h, temperatura de carbonización de 470oC, concentración de ácido fosfórico de 50% en peso y con área BET de 1402 m2 / g. Dicho material mejoró significativamente el comportamiento de almacenamiento de H2 en comparación con el carbón nanoestructurado del tipo CMK-3 (3,1% en peso a -196,15 oC y 10 bar). El material sintetizado es prometedor en la absorción de hidrógeno por fuerzas de enlace débiles (fisisorción).Item Vanadium and titanium oxide supported on mesoporous CMK-3 asnew catalysts for oxidative desulfurization.(Universidad Tecnológica Nacional., 2016) Rivoira , Lorena Paola; Juárez , Juliana María; Falcón , Horacio; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo; Beltramone , Andrea Raquel; Beltramone , Andrea Raquel; Anunziata , Oscar Alfredo; Juárez , Juliana MaríaVanadium supported-CMK-3 catalysts with vanadium loading of 1–7 wt.% were studied in the oxidative desulfurization (ODS) of dibenzothiophene as a model sulfur compound. The activity was compared with titanium supported-CMK-3. Structural and textural characterization of the catalysts was performed by means of N2 adsorption, XRD, UV–vis–DRS, Raman spectroscopy, XPS, TEM and TPR. The dispersion and the nature of the vanadium species depend on the V loading, so does the catalyst activity. Vanadium supported-CMK-3 with 7 wt.% of vanadium loading was the most active catalyst for ODS of DBT using hydrogen peroxide (H2O2) as oxidant and acetonitrile as solvent. 100% of DBT elimination was attained at short time in mild conditions. Carbon ordered mesoporous CMK-3 with high surface area and high pore volume promotes a very good anchorage of metallic oxides in the carbons framework reaching high active sites distribution and more stable nanoclusters. The reusability of the catalyst indicates that V-CMK-3 is a potential catalyst for the ODS of dibenzothiophene.Item Vanadium oxide supported on mesoporous SBA-15 modified with AI and Ga as a highly active catalyst in the ODS of DBT.(Universidad Tecnológica Nacional., 2017) Rivoira , Lorena Paola; Martínez , María Laura; Anunziata , Oscar Alfredo; Beltramone, Andrea Raquel; Beltramone, Andrea Raquel; Anunziata , Oscar Alfredo; Martínez , María LauraVanadium oxides supported on mesoporous SBA-15 catalysts with different vanadium loadings were studied in the oxidative desulfurization (ODS) of dibenzothiophene as a model sulfur compound. The catalytic activity was improved when SBA-15 framework was modified by adding Al and Ga. Structural and textural characterization of the catalysts were performed by means of XRD, N2 adsorption, UVeVis eDRS, XPS, NMR, TEM, Raman, TPR and Py-FTIR. UVeViseDRS and Raman demonstrated that highly dispersed vanadium VO—3 species are responsible for the high activity in the sulfur removal. The Ga modified support with an intermediate V/Si ratio of 1/30 was the most active catalyst for ODS of DBT, using hydrogen peroxide as oxidant and acetonitrile as solvent. 100% of DBT elimination was attained at a short time in mild conditions. Gallium and aluminum incorporation into the support modified suc cessfully the nature of the SBA-15 surface by generating Bronsted and Lewis acidity. The interaction between the acid sites with the active vanadium sites improved the activity of the catalysts. The high dispersion depended on the vanadium loading and on the nature of the support. The more acidic support allowed better dispersion of the vanadium species due to stronger interaction metal-support. The reusability of the catalysts indicates that vanadium oxide supported on mesoporous SBA-15 modified with Ga and Al are potential catalysts for the ODS of dibenzothiophene.Item Synthesis of SBA-1, SBA-3 and SBA-7 mesoporous materials. Study of the effect of time and temperature.(Universidad Tecnológica Nacional., 2016) Martínez , María Laura; Ponte , María Virginia; Falcón , Horacio; Beltramone , Andrea Raquel; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Beltramone , Andrea Raquel; Ponte , María VirginiaIn recent years, physicists, chemists and engineers have focused their research on the design of new functional materials. In the synthesis and control of materials in nanometer dimensions, the aim is currently directed towards the development of systems and devices that take advantage of chemical properties and physical principles, where their causes lie in the nanometer scale. Although there are numerous investigations about the synthesis of mesoporous materials from inorganic silicon salt, for example the synthesis of SBA-3. Ting et al [1] studied the synthesis of SBA-1; they obtained mesoporous SBA-1 with cubic structures, with a high porous system, by utilizing agents’ routers short chain structure such as the dodecyltrimethyl ammonium chloride. Recent research also showed that the formation of mesophases is affected by the presence of the counter ions and templates or surfactants can adopt a mesophase or other phases. So, Che et al. [2] found a phase shift 2D-hexagonal cubes from P6mm to Pm3n. We have published results for synthesis of SBA-3 with silica gel as silica source; we have found that the formation of mesophase is function of NaOH concentration in the dissolutions of silica gel. The influence of reaction temperature, time and NaOH concentration was investigated. During studies for the best synthesis conditions for synthesis of SBA-3, we also obtained SBA-1 and SBA-7 mesoporous materials.Item Óxidos de vanadio y titanio soportados sobre CMK-3 como un nuevo catalizador para la desulfuración oxidativa de DBT.(Universidad Tecnológica Nacional., 2016) Beltramone , Andrea Raquel; Anunziata , Oscar Alfredo; Gómez Costa , Marcos Bruno; Falcón , Horacio; Juárez , Juliana Maria; Rivoira , Lorena Paola; Rivoira , Lorena Paola; Juárez , Juliana Maria; Anunziata , Oscar AlfredoEn el presente trabajo se estudiaron catalizadores de vanadio soportados sobre el carbón mesoporosos CMK 3 con diferentes contenidos de Vanadio (1-7 % p/p) en la desulfurización oxidativa de dibenzotiofeno (DBT) como modelo de compuestos sulfurados. La actividad catalítica se comparó con catalizadores de Titanio soportados en CMK-3. Las propiedades estructurales y texturales de los catalizadores se analizaron mediante estudios de adsorción de N2, XRD, UV-Vis-DRS y TEM. Tanto la dispersión como la actividad catalítica dependen fuertemente del contenido de vanadio. La muestra que contiene el 7% p/p de Vanadio es el catalizador con mejor actividad catalítica para la reacción de ODS de DBT utilizando peróxido de hidrógeno ((H2O2) como oxidante y acetonitrilo como solvente. El 100% de la eliminación de DBT se alcanzó a corto plazo en condiciones suaves. El carbon mesoporoso CMK-3 con una alta área superficial y gran volumen de poros promueve el anclaje del metal en la red de carbono, lo que permite alcanzar una alta distribución de sitios activos y nanoclusters más estables. La reutilización del catalizador indica que V-CMK-3 es un catalizador potencial para los ODS de dibenzotiofeno.