KETO/LP-SBA-15 Composite as a drug release system.
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Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Tecnológica Nacional Regional Córdoba.
Abstract
Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the
body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and
reducing toxicity. SBA-15 with larger pore sizes material (LP-SBA-15) is a new promising host for
drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Large pore mesoporous silica supports has been applied in studies of ketorolac tromethamine (KETO)
adsorption and release. KETO/LP-SBA-15 composite was synthesized. The material synthesis and
loading of KETO into LP-SBA-15 pores were successful. We obtained promising results for controlled
drug release using the novel LP-SBA-15 material. The ability of KETO/LP-SBA-15 release was
measured. The concentration of KETO in HCl solution or buffer in a specific time was determined
by UV-Vis. First-order, Higuchi and Ritger-Peppas (or Korsmeyer-Peppas) models were used to fit
experimental release data. Figure 1 show the fitting results, where Qt/Q? is the release fraction per
unit mass in time t, k represents release rate in all models and n is a measure of desorption
intensity in Ritger-Peppas regression. In this work, we have shown a promising drug storage
material for the effective encapsulation and controlled release of KETO, achieving the required
therapeutic efficacy. KETO was adsorbed into LP-SBA-15 channel surface without affecting the
chemical structure or composition of KETO. The study also demonstrates the storage capacity and
release properties of LP-SBA-15 containing KETO. The release of KETO contained in LP-SBA-15 can
offer significant improve in controlled drug release and enhance a good analgesia effect.
Description
Keywords
Drug Delivery Systems, LP-SBA-15, Ketorolac Tromethamine
Citation
XXVIII International Materials Research Congress.
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