Facultad Regional Córdoba
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Item Preparation, charactrization and mathematical modeling of keterolac reléase conteined in LP-SBA-15 host.(Universidad Tecnológica Nacional Regional Córdoba., 2017) Cussa , Jorgelina; Juárez , Juliana María; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Juárez , Juliana MaríaDrug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the LP-SBA-15 nanomaterial as a promising new host for drug delivery systems because of its high biocompatibility, in vivo biodegradability, and low toxicity. Ketorolac-LP-SBA-15 was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release, achieving the required therapeutic efficacy. The host shows ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, being the Ritger-Peppas model followed by the Weibull model the best ones. In this work, we show a promising drug storage material for effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. Studies indicate that KETO was adsorbed on the channel surface of LP-SBA-15 without affecting the structure or chemical composition of KETO. Controlled drug delivery systems can achieve precise delivery at the time and place of destination, keeping the concentration of the drug at points in the body within the optimal range and below the toxicity threshold. The study also demonstrates the storage capacity and release properties of LP SBA-15 containing KETO. The release of KETO contained in LP-SBA-15 can offer a significant improvement in the controlled release of the drug and the analgesic and anti-inflammatory effects, positively influenced, by the links formed between the host and drug molecules and by diffusion through the host porosity. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response.Item KETO/LP-SBA-15 Composite as a drug release system.(Universidad Tecnológica Nacional Regional Córdoba., 2017) Cussa , Jorgelina; Juárez , Juliana María; Prados, Antonela; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Juárez , Juliana MaríaControlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. SBA-15 with larger pore sizes material (LP-SBA-15) is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Large pore mesoporous silica supports has been applied in studies of ketorolac tromethamine (KETO) adsorption and release. KETO/LP-SBA-15 composite was synthesized. The material synthesis and loading of KETO into LP-SBA-15 pores were successful. We obtained promising results for controlled drug release using the novel LP-SBA-15 material. The ability of KETO/LP-SBA-15 release was measured. The concentration of KETO in HCl solution or buffer in a specific time was determined by UV-Vis. First-order, Higuchi and Ritger-Peppas (or Korsmeyer-Peppas) models were used to fit experimental release data. Figure 1 show the fitting results, where Qt/Q? is the release fraction per unit mass in time t, k represents release rate in all models and n is a measure of desorption intensity in Ritger-Peppas regression. In this work, we have shown a promising drug storage material for the effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. KETO was adsorbed into LP-SBA-15 channel surface without affecting the chemical structure or composition of KETO. The study also demonstrates the storage capacity and release properties of LP-SBA-15 containing KETO. The release of KETO contained in LP-SBA-15 can offer significant improve in controlled drug release and enhance a good analgesia effect.Item Composite MCF/KETO. Aplicación en sistemas de liberación de fármacos.(Universidad Tecnológica Nacional Regional Córdoba., 2019) Cussa , jorgelina; Juárez , Juliana María; Prados, Antonela; Gómez Costa, Marcos Bruno; Juárez , Juliana MaríaLa espuma celular mesoestructurada (MCF) es un prometedor material para los sistemas de administración de fármacos dado a la alta biocompatibilidad, biodegradabilidad y baja toxicidad. Sus propiedades incluyen una gran área superficial, poro grande uniforme. En este trabajo, MCF como material de almacenamiento de drogas fue sintetizado con éxito y cargado con la droga ketorolaco-trometamina, obteniendo el composite MCF/ KETO. La síntesis del material y el proceso de carga de ketorolaco-trometamina en los poros de la MCF fueron exitosos tal como se muestra en los análisis de XRD, FTIR, TGA, TEM y texturales. Hemos obtenido resultados prometedores para la liberación controlada de fármacos utilizando el noble material MCF. La aplicación de estos materiales en la liberación de KETO es innovadora, logrando una alta tasa de liberación inicial y manteniendo una tasa constante en los tiempos altos.Item Nanocomposite aplicados a la liberación controlada de fármacos.(Universidad Tecnológica Nacional Regional Córdoba., 2020) Cussa, Jorgelina; Prados, Antonella; Gómez Costa , Marcos Bruno; Juárez , Juliana María; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Juárez , Juliana MaríaLas nanomedicinas terapéuticas pueden transportar Principio Activo (PA) hasta los tejidos patológicos, consiguiendo que las células enfermas reciban una gran descarga de PA y disminuyendo el acceso del PA sobre las células sanas. El objetivo principal de este estudio es determinar la capacidad adsorción y las propiedades de almacenamiento de la LP-SBA 15/KETO y la liberación logrando la eficacia terapéutica requeridaItem Bimetallic platinum/iridium modified mesoporous catalysts applied in the hydrogenation of HMF.(Universidad Tecnológica Nacional Regional Córdoba., 2018) Ledesma , Brenda Cecilia; Juárez , Juliana María; Beltramone , Andrea Raquel; Beltramone , Andrea Raquel; Juárez , Juliana MaríaThe catalytic transformation of 5-hydroxymethylfurfural (HMF) to produce 2,5-dimethylfuran (DMF) was studied over bimetallic (PtIr) and monometallic (Pt) catalysts supported on CMK-3 and SBA-15 mesoporous materials. The optimum temperature and pressure for the maximum production of DMF were 120° and 15 atm. Increases in temperature and pressure decreased the selectivity to DMF. The catalysts were broadly characterized by XRD, N2-isotherms, XPS, TPR, TEM and NH3-TPD. It was found that the metal particles were well reduced and highly dispersed on the surface of the support of large surface area and narrow pore distribution. The PtIr alloy species active sites were very active and selective towards the formation of the desired DMF. PtIr-CMK-3 showed an excellent activity, selectivity and stability to be applied in this process.Item Reservorio nanoscópico de hidrógeno a partir de biorresiduos de casacara de naranjas.(Universidad Tecnológica Nacional., 2022) Juárez , Juliana María; Ledesma , Brenda Cecilia; Anunziata , Oscar Alfredo; Gómez Costas , Marcos Bruno; Beltramone, Andrea Raquel; Beltramone, Andrea Raquel; Anunziata , Oscar Alfredo; Ledesma , Brenda CeciliaEste trabajo aborda el enfoque de valorización de biorresiduos para el desarrollo de un novedoso nanomaterial carbonoso para ser utilizado en la adsorción de hidrógeno como una alternativa en el uso de hidrógeno verde. En esta investigación, los carbones activados se sintetizaron a partir de cáscara de naranja utilizando diferentes condiciones de síntesis. Con los carbones activados obtenidos con la mejor estructura y textura se estudió la adsorción de hidrógeno y los efectos en la meso/microporosidad de estos. La activación del carbón se realizó mediante un proceso químico con ácido fosfórico como agente activador, variando la concentración de ácido, la relación sustrato / agente activador y el tiempo de contacto entre ellos. El mejor material se obtuvo utilizando tiempo de carbonización de 1 h, temperatura de carbonización de 470oC, concentración de ácido fosfórico de 50% en peso y con área BET de 1402 m2 / g. Dicho material mejoró significativamente el comportamiento de almacenamiento de H2 en comparación con el carbón nanoestructurado del tipo CMK-3 (3,1% en peso a -196,15 oC y 10 bar). El material sintetizado es prometedor en la absorción de hidrógeno por fuerzas de enlace débiles (fisisorción).Item Synthesis and characterization of a nanoporous carbon CMK-3 modified with iron for the ODS of DBT.(Universidad Tecnológica Nacional., 2017) Juárez , Juliana María; Rivoira , Lorena Paola; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo; Beltramone , Andrea Raquel; Anunziata , Oscar Alfredo; Rivoira , Lorena PaolaA nanostructured Carbon CMK-3 modified with Fe by using different sources of Fe, were used in the oxidative desulfurization (ODS) of dibenzothiophene as a model sulfur compound. Ordered mesoporous carbon CMK-3 was synthesized via a two-step impregnation of the SBA-15 silica mesonanopores with a solution of sucrose using an incipient wetness method. The sucrose–silica composite was heated at 1173 K for 4 h under nitrogen flow. The silica A nanostructured Carbon CMK-3 modified with Fe by using different sources of Fe, were used in the oxidative desulfurization (ODS) of dibenzothiophene as a model sulfur compound. Ordered mesoporous carbon CMK-3 was synthesized via a two-step impregnation of the SBA-15 silica mesonanopores with a solution of sucrose using an incipient wetness method. The sucrose–silica composite was heated at 1173 K for 4 h under nitrogen flow. The silica The catalytic activity was improved when the nanoporous carbon was modified with Fe. The sample modified with FeCl3.6H2O was the most active catalyst for ODS of DBT, using hydrogen peroxide (H2O2) as oxidant and acetonitrile as solvent. 100% of DBT elimination was attained at a short time in mild conditions.Item Novel preparation of titania-modified CMK-3 nanostructured material as support for Ir catalyst applied in hydrodenitrogenation of indole.(Universidad Tecnológica Nacional., 2017) Ledesma , Brenda Cecilia; Juárez , Juliana María; Vallés , Verónica Alejandra; Anunziata , Oscar Alfredo; Beltramone , Andrea Raquel; Anunziata , Oscar Alfredo; Vallés , Verónica Alejandra; Juárez , Juliana MaríaIridium catalyst was prepared using a novel titanium oxide-CMK-3 support synthesized as a replica of Ti-SBA-15. The catalyst was applied in the hydrodenitrogenation of indole. The activity was compared with an iridium catalyst supported over a grafted titanium CMK-3. Structural and textural characterization of the catalysts was performed by means of N2 adsorption, XRD, UV–Vis–DRS, Raman spectroscopy, XPS, TEM and H2 Chemisorption. Ir-Ti-CMK-3 was the most active catalyst for the hydrodenitrogenation reaction at mild conditions. Titanium oxide contained in carbon ordered mesoporous CMK-3 promotes a very good anchorage of iridium metallic clusters in the carbon framework reaching high active site distribution and more stable nanoclusters.Item Preparation of carbon nanotubes with hybrids nanostructure materials.(Universidad Tecnológica Nacional., 2017) Martínez , María Laura; Juárez , Juliana María; Gómez Costa, Marcos Bruno; Beltramone, Andrea Raquel; Juárez , Juliana MaríaCarbon nanotubes (CNT's) are allotropes carbon, like diamond, graphite and fullerenes. There are different types of CNT's, depending on the type of the graphite layers, it can be single wall carbon nanotubes (SWCNT's) and multi wall carbon nanotubes (MWCNT's). These nanomaterials show good physical properties such as their density, strength and thermal conductivity. The controllable synthesis of materials with the desired structure and dimensionality is of great significance in material science. In this work, the hierarchical carbon nanotubes (CNTs) were synthesized via a simple chemical conversion route by using Carbon Substrate/Fe3O4-SBA-15 hybrid (all in one). The synthesis of Carbon Substrate/Fe3O4-SBA-15 hybrid was carried out using Fe3O4- SBA-15 as a hard template and sucrose as carbon precursor. Sucrose was dissolved in a solution of H2SO4 in water and to this solution, Fe3O4-SBA-15 was added. The resulting mixture was dried at 373 K and then heated at 433 K for 6 h. A second impregnation was performed in order to ensure the filling of the template pores with the carbon precursor. To obtain the carbon nanotubes, the sample was placed in muffle at 1173 K under nitrogen flow (20mL/min) for 30 min. In order to remove the silica, the material was placed in an HF solution. The CNTs was filtered, washed and dried at 323 K. In the present work, we report the synthesis and characterization of CNTs materials of hybrid material. The material was characterized by X-ray diffraction (XRD) and the morphologies and structural features of the prepared materials were observed from the SEM and TEM images.Item SINTESIS DIRECTA DE CMK-3 MODIFICADA CON TI, COMO SOPORTE DE IR APLICADO A REACCIONES DE HIDRODENITROGENACION.(Universidad Tecnológica Nacional., 2018) Ledesma , Brenda Cecilia; Juárez , Juliana María; Beltramone, Andrea Raquel; Juárez , Juliana MaríaEn el presente trabajo se sintetizó Ti-CMK-3 mediante un nuevo método de síntesis, en el cual se evita la utilización de un molde, con el fin de reducir el tiempo, el consumo de energía y por ende el costo. La caracterización estructural y superficial del catalizador se realizó mediante adsorción de N2, XRD, UV-Vis DRS, espectroscopía Raman y TEM. Los resultados de la caracterización indicaron que las propiedades texturales y estructurales del material sintetizado son comparables con las propiedades del material preparado por el método tradicional. El catalizador Ir-Ti-CMK-3 obtenido fue activo y selectivo para la reacción de hidrodenitrogenación (HDN) del indol. La principal ventaja del presente estudio es la reducción de tiempo y costo de la síntesis, simultáneamente con la aplicabilidad en las reacciones de Hidrotratamiento (HDT)