UTN- FRC -Producción Académica de Investigación y Desarrollo
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Item Preparation and characterization of activated CMK-3 modified with vanadium applied in hydrogen storage(XXIII INTERNATIONAL MATERIALS RESEARCH CONGRESS, 2014) Juárez, Juliana; Gómez Costa, Marcos; Cussa, Jorgelina; Anunziata, OscarThe aim of this work is to synthesize a nanostructured Carbon CMK-3 modified with V in order to increase its capacity in hydrogen storage. The approach that we have followed includes synthesis of nanostructures with the experimental study of its adsorption capacity and storage properties. Ordered nanoporous carbon CMK-3 was synthesized via a two-step impregnation of the SBA-15 mesopores with a solution of sucrose using an incipient wetness method. The sucrose–silica composite was heated at 1173 K for 4 h under nitrogen flow. The silica template was dissolved with 5 wt% hydrofluoric acid in order to remove the silica. The template-free carbon product thus obtained was filtered, washed with deionized water and ethanol, and dried. [1] V-CMK-3 was prepared by wetness impregnation using VCl3 as source of Vanadium in order to increase the amount of hydrogen adsorbed. The sample of V-CMK-3 was treated under H2 flow two times at 1173 K. Porous carbon CMK-3 and the sample modified with V were characterized by XRD, FTIR, XPS, BET, TEM and SEM. These studies indicate that it was possible to obtain a CMK-3 replica successfully from SBA-15, using sucrose as a carbon precursor. [2] The surface areas are 1320 m2/g and 1050 m2/g for CMK-3 and V-CMK-3, respectively. While the nanomaterial area is significantly smaller with the incorporation of the metal, CMK-3`s characteristic structure is maintained after the metal is within the host, in agreement with the XRD studies. Measurements of hydrogen adsorption at cryogenic temperatures and low pressures were performed. The nanoparticles of V incorporated onto the nanostructured carbon CMK-3 showed higher hydrogen uptake at low and high pressures than CMK-3. (3.4 wt% and 2.2 wt% respectively of H2 sorption at 10 bar and 77 K).Item Tetralin hydrogenation over Pt-Ir/SBA-15. optimization by experimental desing.(XXIV International material research congress, 2015) Vallés, Verónica; Ledesma, Brenda; Rivoira, Lorena; Cussa, Jorgelina; Anunziata, Oscar; Beltramone, AndreaThe oil refining industry has a difficult challenge to meet the increasingly stringent regula tions on environmental issues. Contaminants such as sulfur, nitrogen, fused ring aromatic compounds or metals are the principal to remove to achieve "green" fuels. The hydrotreating (HDT) is one of the processes most used in the refinery to remove these contaminants. To optimize the gas oil hydrotreater, it is crucial to understand the aromatic hydrogenation reaction chemistry occurring in the gas oil hydrotreater. To find alternative processes, it is neces sary to develop new and more active catalysts to replace the current ones. Bimetallic Pt–Pd catalysts have received considerable attention, because they show high actvity in a variety of catalytic applications [1,2]. From a fundamental point of view, exploring bimetallic catalysts also allows better understanding of mechanisms and variables involved in the catalytic reactions. The features of the catalysts here studied are going to be correlated with their catalytic performance in the hydrogenation of tetralin. The final goal is to find the optimal proportion of each metal in order to be more active and the best reaction conditions. The statistical expe riments design is the process of planning an experiment to obtain appropriate data that can be analyzed by statistical methods, to produce concrete and valid conclusions [3]. One of the main advantages in the response curve is to visualize the response for all levels of the experi mental factors Experiment design response surface methodology (RSM) is used in this work to model and to optimize the process.Item Experimental desing optimization of the tetralin hydrogenation over Ptlr/SBA-15(International Symposium on Advances in Hydroprocessing of Oil Fractions, 2015) Valles, Verónica; Ledesma, Brenda; Rivoira, Lorena; Cussa, Jorgelina; Anunziata, Oscar; Beltramone, AndreaThe oil refining industry has a difficult challenge to meet the increasingly stringent regula tions on environmental issues. Contaminants such as sulfur, nitrogen, fused ring aromatic compounds or metals are the principal to remove to achieve "green" fuels. The hydrotreating (HDT) is one of the processes most used in the refinery to remove these contaminants. To optimize the gas oil hydrotreater, it is crucial to understand the aromatic hydrogenation reaction chemistry occurring in the gas oil hydrotreater. To find alternative processes, it is necessary to develop new and more active catalysts to replace the current ones. Bimetallic Pt–Pd catalysts have received considerable attention, because they show high actvity in a variety of catalytic applications [1,2]. From a fundamental point of view, exploring bimetallic catalysts also allows better understanding of mechanisms and variables involved in the catalytic reac tions. The features of the catalysts here studied are going to be correlated with their catalytic performance in the hydrogenation of tetralin. The final goal is to find the optimal proportion of each metal in order to be more active and the best reaction conditions. The statistical experiments design is the process of planning an experiment to obtain appropriate data that can be analyzed by statistical methods, to produce concrete and valid conclusions [3]. One of the main advantages in the response curve is to visualize the response for all levels of the experi mental factors Experiment design response surface methodology (RSM) is used in this work to model and to optimize the process.Item Nanocomposite aplicados a la liberación controlada de fármacos.(Universidad Tecnológica Nacional Regional Córdoba., 2020) Cussa, Jorgelina; Prados, Antonella; Gómez Costa , Marcos Bruno; Juárez , Juliana María; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Juárez , Juliana MaríaLas nanomedicinas terapéuticas pueden transportar Principio Activo (PA) hasta los tejidos patológicos, consiguiendo que las células enfermas reciban una gran descarga de PA y disminuyendo el acceso del PA sobre las células sanas. El objetivo principal de este estudio es determinar la capacidad adsorción y las propiedades de almacenamiento de la LP-SBA 15/KETO y la liberación logrando la eficacia terapéutica requeridaItem LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release.(Universidad Tecnológica Nacional Regional Córdoba., 2023) Cussa, Jorgelina; Juárez , Juliana María; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Juárez , Juliana MaríaDrug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the nanomaterial LP-SBA-15 as an attractive new host for drug delivery systems due to its high biocompatibility, in vivo biodegradability, and low toxicity. LP-SBA-15/Ketorolac was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release and achieving the required therapeutic efficacy. The host shows the ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release from the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, the Ritger-Peppas model followed by the Weibull model the best ones. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid responseItem Tetralin hydrogenation and ring opening of decalin over Ir-Pt-SBA-15(CICat, 2014) Vallés, Verónica Alejandra; Rivoira, Lorena Paola; Ledesma, Brenda Cecilia; Cussa, Jorgelina; Anunziata, Oscar Alfredo; Beltramone, Andrea RaquelA series of Ir and Pt modified SBA-15 were prepared by the consecutive wet impregnation method, with different content of each metal. The final catalysts were characterized by XRD, TEM and H2 chemisorption to study the effect of content of metal on the dispersion of iridium/platinum. The catalysts synthesized with similar percentage of both metals showed the best activity measured in tetralin hydrogenation and ring opening of decalin at mild conditions.Item Optimización de la sínstesis del material mesoestructurado SBA-3 mediante diseño experimental(CICat, 2016) Ponte , María Virginia; Rivoira, Lorena Paola; Cussa, Jorgelina; Martínez, María Laura; Beltramone, Andrea Raquelhexagonal, diámetro de poro >3nm; presenta alta área superficial y alto volumen de poro. Se utilizó la metodología de Superficie de Respuesta para el modelado y optimización de las condiciones de síntesis de SBA‐3. Se analizaron como factores del Diseño la influencia de la relación molar entre el surfactante (CTAB) y la fuente de silicio (TEOS), el tiempo de envejecimiento, la temperatura y el pH de la síntesis utilizando HCl. La respuesta analizada fue la intensidad de difracción de rayos X para el plano [100]. Las superficies de respuestas se obtuvieron con el diseño Box–Behnken, buscando la combinación de los parámetros que dieran como resultado la mejor estructura en el material sintetizado. Mediante la aplicación de metodología estadística, los mayores valores de la función objetivo (intensidad de DRX para el plano [100]) se obtuvieron utilizando valores de la relación molar CTAB/TEOS de 0,07‐0,16; HCl/TEOS de 8‐11; temperatura de síntesis de 35‐45 (ºC) y tiempos de envejecimiento de 12‐24hr.Item KETO/LP-SBA-15 composite as a drug release system(Materials Research Society, 2018) Cussa, Jorgelina; Juárez, Juliana María; Prados , Antonela M.; Gómez Costa , Marcos Bruno; Anunziata, Oscar AlfredoControlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. SBA-15 with larger pore sizes material (LPSBA- 15) is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Large-pore mesoporous silica supports has been applied in studies of ketorolac tromethamine (KETO) adsorption and release. KETO/LP-SBA-15 composite was synthesized. The material synthesis and loading of KETO into LP-SBA-15 pores were successful. We obtained promising results for controlled drug release using the novel LP-SBA-15 material. The ability of KETO/LP-SBA-15 release was measured. The concentration of KETO in HCl solution or buffer in a specific time was determined by UV-Vis. First-order, Higuchi and Ritger-Peppas (or Korsmeyer-Peppas) models were used to fit experimental release data. Figure 1 show the fitting results, where Qt/Q∞ is the release fraction per unit mass in time t, k represents release rate in all models and n is a measure of desorption intensity in Ritger-Peppas regression. In this work, we have shown a promising drug storage material for the effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. KETO was adsorbed into LP-SBA-15 channel surface without affecting the chemical structure or composition of KETO. The study also demonstrates the storage capacity and release properties of LP-SBA-15 containing KETO. The release of KETO contained in LP-SBA-15 can offer significant improve in controlled drug release and enhance a good analgesia effect.Item Experimental Desing Optimization of the tetralin Hydrogenation over Pt-Ir/SBA-15.(Univesidsad Tecnológica Nacional., 2015) Vallés , Verónica Alejandra; Ledesma , Brenda Cecilia; Rivoira , Lorena Paola; Cussa, Jorgelina; Anunziata , Oscar Alfredo; Beltramone, Andrea Raquelhe oil refining industry has a difficult challenge to meet the increasingly stringent regula tions on environmental issues. Contaminants such as sulfur, nitrogen, fused ring aromatic compounds or metals are the principal to remove to achieve "green" fuels. The hydrotreating (HDT) is one of the processes most used in the refinery to remove these contaminants. To optimize the gas oil hydrotreater, it is crucial to understand the aromatic hydrogenation reac tion chemistry occurring in the gas oil hydrotreater. To find alternative processes, it is neces sary to develop new and more active catalysts to replace the current ones. Bimetallic Pt–Pd catalysts have received considerable attention, because they show high actvity in a variety of catalytic applications [1,2]. From a fundamental point of view, exploring bimetallic catalysts also allows better understanding of mechanisms and variables involved in the catalytic reac tions. The features of the catalysts here studied are going to be correlated with their catalytic performance in the hydrogenation of tetralin. The final goal is to find the optimal proportion of each metal in order to be more active and the best reaction conditions. The statistical expe riments design is the process of planning an experiment to obtain appropriate data that can be analyzed by statistical methods, to produce concrete and valid conclusions [3]. One of the main advantages in the response curve is to visualize the response for all levels of the experi mental factors Experiment design response surface methodology (RSM) is used in this work to model and to optimize the process.Item Experimental Desing Optimization of the tetralin Hydrogenation over Pt-Ir/SBA-15.(Univesidsad Tecnológica Nacional, 2015) Vallés , Verónica Alejandra; Ledesma , Brenda Cecilia; Rivoira , Lorena Paola; Cussa, Jorgelina; Anunziata , Oscar Alfredo; Beltramone, Andrea RaquelThe oil refining industry has a difficult challenge to meet the increasingly stringent regula tions on environmental issues. Contaminants such as sulfur, nitrogen, fused ring aromatic compounds or metals are the principal to remove to achieve "green" fuels. The hydrotreating (HDT) is one of the processes most used in the refinery to remove these contaminants. To optimize the gas oil hydrotreater, it is crucial to understand the aromatic hydrogenation reac tion chemistry occurring in the gas oil hydrotreater. To find alternative processes, it is neces sary to develop new and more active catalysts to replace the current ones. Bimetallic Pt–Pd catalysts have received considerable attention, because they show high actvity in a variety of catalytic applications [1,2]. From a fundamental point of view, exploring bimetallic catalysts also allows better understanding of mechanisms and variables involved in the catalytic reac tions. The features of the catalysts here studied are going to be correlated with their catalytic performance in the hydrogenation of tetralin. The final goal is to find the optimal proportion of each metal in order to be more active and the best reaction conditions. The statistical expe riments design is the process of planning an experiment to obtain appropriate data that can be analyzed by statistical methods, to produce concrete and valid conclusions [3]. One of the main advantages in the response curve is to visualize the response for all levels of the experi mental factors Experiment design response surface methodology (RSM) is used in this work to model and to optimize the process