UTN- FRC -Producción Académica de Investigación y Desarrollo

Permanent URI for this communityhttp://48.217.138.120/handle/20.500.12272/1932

Browse

Start date: 2020Author: search.filters.author.Anunziata, Oscar A.Author: search.filters.author.Cussa, Jorgelina

Search Results

Now showing 1 - 5 of 5
  • Thumbnail Image
    Item
    Sistema de liberación controlada de fármacos: espuma mesoporosa MCF-clorambucilo
    (2022) Juárez, Juliana M.; Cussa, Jorgelina; Anunziata, Oscar A.; Gómez Costa, Marcos Bruno
    La espuma celular mesoestructurada (MCF) es un material prometedor para los sistemas de administración de fármacos dado a la alta biocompatibilidad, biodegradabilidad y baja toxicidad. Sus propiedades incluyen una gran área superficial, poro grande uniforme. En este trabajo, la espuma mesoporosa MCF fue sintetizada con éxito para su aplicación en nanotransportadores de fármacos, específicamente de Clorambucilo, obteniendo el composite MCF-CBL. La síntesis del material mesoporoso y el proceso de incorporación de Clorambucilo en los poros de la MCF fueron exitosos tal como se muestra en los análisis de XRD, FTIR, TEM y análisis de propiedades texturales. La liberación del fármaco se realizó simulando las condiciones fisiológicas para reproducir las condiciones del organismo. Se evaluó el mecanismo de liberación del fármaco en el hospedaje MCF-CLB. Se utilizaron diferentes modelos matemáticos para ajustar los datos experimentales, el mejor modelo que describe el fenómeno en estudio durante todo el período es el modelo de Weibull. Los resultados auspiciosos que obtuvimos para la liberación del fármaco utilizando el nuevo material, la principal ventaja de esta liberación es que la velocidad de liberación es rápida al inicio y luego disminuye gradualmente hasta que se liberan 24 h prácticamente todo el fármaco contenido en el portador. (> 95%).
  • Thumbnail Image
    Item
    Sistema de liberación controlada de fármacos: espuma mesoporosa MCFClorambucilo
    (2022) Juárez, Juliana María; Cussa, Jorgelina; Gómez Costa, Marcos Bruno; Anunziata, Oscar A.;
    La espuma celular mesoestructurada (MCF) es un material prometedor para los sistemas de administración de fármacos dado a la alta biocompatibilidad, biodegradabilidad y baja toxicidad. Sus propiedades incluyen una gran área superficial, poro grande uniforme. En este trabajo, la espuma mesoporosa MCF fue sintetizada con éxito para su aplicación en nanotransportadores de fármacos, específicamente de Clorambucilo, obteniendo el composite MCFCBL. La síntesis del material mesoporoso y el proceso de incorporación de Clorambucilo en los poros de la MCF fueron exitosos tal como se muestra en los análisis de XRD, FTIR, TEM y análisis de propiedades texturales. La liberación del fármaco se realizó simulando las condiciones fisiológicas para reproducir las condiciones del organismo. Se evaluó el mecanismo de liberación del fármaco en el hospedaje MCFCLB. Se utilizaron diferentes modelos matemáticos para ajustar los datos experimentales, el mejor modelo que describe el fenómeno en estudio durante todo el período es el modelo de Weibull. Los resultados auspiciosos que obtuvimos para la liberación del fármaco utilizando el nuevo material, la principal ventaja de esta liberación es que la velocidad de liberación es rápida al inicio y luego disminuye gradualmente hasta que se liberan 24 h prácticamente todo el fármaco contenido en el portador. (> 95%).
  • Thumbnail Image
    Item
    HaP / LP-SBA-15 Nanocomposite for efficient removal of fluoride from contaminated wáter
    (2020) López, Claudia G.; Anunziata, Oscar A.; Cussa, Jorgelina
    Hydroxyapatite (HaP) composites and highly ordered large pore mesoporous silica, such as LP-SBA-15 (Large Pore-SBA-15), were developed, characterized by XRD, BET, FTIR and HRTEM, and applied properly to fluoride removal from contaminated water. The proposed procedure to prepare HaP/LP-SBA-15 was successful, which acts as supports to anchor the HaP crystals, in nanometer-scale (<12 nm), with higher fluoride retention from contaminated water. The free OH- groups of HaP nanocrystals, inside the host, permitted fluoride retention with high capacity. The fluoride holding activity was over 3 orders of magnitude higher than pure HaP.
  • Thumbnail Image
    Item
    Synthesis, characterization and application of mesoporous materials in the controlled release of ibuprofen
    (2020) Cussa, Jorgelina; Anunziata, Oscar A.
    Drug delivery systems consist of an active ingredient and a carrier system that can direct the release of the drug to the appropriate site and in the appropriate amount. The characteristics that these vehicles must meet are low toxicity, optimal properties for drug transport and release, and long half-life. Three mesoporous materials are reported in this work, the first one containing lattice aluminum; named Al-Si/SBA-3; the second one containing magnesium; named Mg-SBA-3, and the third one named LP-SBA-15. These materials were characterized by X-ray diffraction, resulting in hexagonal porous nanostructures, with lattice parameters of 3.63 nm for Al-Si/SBA-3 (without significant changes in the periodicity of the lattice). LP-SBA-15 is a novel large porous nanomaterial. It is encouraging the results of the application of these materials as host-transporters in the study of the modified release of Ibuprofen. LP-SBA-15 appears to be the most promising delivery system for IBU and its controlled release.
  • Thumbnail Image
    Item
    Preparation, characterization and mathematical modeling of keterolac release conteined in lpsba-15 host
    (2021) Cussa, Jorgelina; Juárez, Juliana M.; Gómez Costa, Marcos B.; Anunziata, Oscar A.
    Drug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the LP-SBA-15 nanomaterial as a promising new host for drug delivery systems because of its high biocompatibility, in vivo biodegradability, and low toxicity. Ketorolac-LP-SBA-15 was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release, achieving the required therapeutic efficacy. The host shows ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, being the Ritger-Peppas model followed by the Weibull model the best ones. In this work, we show a promising drug storage material for effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. Studies indicate that KETO was adsorbed on the channel surface of LP-SBA-15 without affecting the structure or chemical composition of KETO. Controlled drug delivery systems can achieve precise delivery at the time and place of destination, keeping the concentration of the drug at points in the body within the optimal range and below the toxicity threshold. The study also demonstrates the storage capacity and release properties of LPSBA- 15 containing KETO. The release of KETO contained in LP-SBA-15 can offer a significant improvement in the controlled release of the drug and the analgesic and anti-inflammatory effects, positively influenced, by the links formed between the host and drug molecules and by diffusion through the host porosity. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response.