Browsing by Author "Cussa, Jorgelina"
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Item Controlled drug release system: MCF-Chlorambucil mesoporous foam(2022) Juárez, Juliana M.; Cussa, Jorgelina; Anunziata, Oscar Alfredo; Goméz Costa, Marcos BrunoMesostructured cellular foam (MCF) is a promising material for drug delivery systems due to its high biocompatibi0lity, biodegradability, and low toxicity. Its properties include a large surface area, uniform large pore. In this work, the MCF mesoporous foam was successfully synthesized for its application in drug nanocarriers, specifically Chlorambucil, obtaining the MCF-CLB composite. The synthesis of the mesoporous material and the process of incorporation of Chlorambucil in the pores of the MCF were successful as shown in the XRD, UV Vis Ref. Difusa, TEM analysis and analysis of textural properties. The release of the drug was conducted by simulating the physiological conditions to reproduce the conditions of the organism. The mechanism of drug release from the MCF-CLB host was evaluated. Different mathematical models were used to adjust the experimental data, the best model describing the phenomenon under study over the entire period is the Weibull model. The auspicious results we attained for the release of the drug using the new material, the main advantage of this release is that the rate of release is fast at the beginning and then gradually decreases until 24 h practically all the drug contained in the carrier is released (>95%).Item Drug delivery system: large pore SBA-15 as host for ketorolac tromethamine(2022) Juárez, Juliana María; Cussa, Jorgelina; Anunziata, Oscar Alfredo; Gómez Costa, Marcos BrunoDrug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the LP-SBA-15 nanomaterial as a promising new host for drug delivery systems because of its high biocompatibility, in vivo biodegradability, and low toxicity. Ketorolac-LP-SBA-15 was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release, achieving the required therapeutic efficacy. The host shows ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, being the Ritger-Peppas model followed by the Weibull model the best ones. In this work, we show a promising drug storage material for effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. Studies indicate that KETO was adsorbed on the channel surface of LP-SBA-15 without affecting the structure or chemical composition of KETO. Controlled drug delivery systems can achieve precise delivery at the time and place of destination, keeping the concentration of the drug at points in the body within the optimal range and below the toxicity threshold. The study also demonstrates the storage capacity and release properties of LPSBA-15 containing KETO. The release of KETO contained in LP-SBA-15 can offer a significant improvement in the controlled release of the drug and the analgesic and anti-inflammatory effects, positively influenced, by the links formed between the host and drug molecules and by diffusion through the host porosity. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response.Item EXperimental design optimization of the ODS of DBT using vanadium oXide supported on mesoporous Ga-SBA-15(2020) Rivoira, Lorena Paola; Cussa, Jorgelina; Martínez, María Laura; Beltramone, Andrea RaquelEXperiment design-response surface methodology is applied in this work to model and optimize the o Xidation of dibenzothiophene (DBT) using VOX-Ga-SBA-15 catalyst. The analyzed variables are the influence of the nature of the catalyst (V and Ga loading), the s ubstrate/catalyst mass ratio (g DBT/g of catalyst) and the o Xidant/substrate molar ratio (H2O2/DBT). The response analyzed is conversion of DBT at 15 min of reaction time. A set of re- sponse surfaces were obtained applying the BoX-Behnken Design. Based on statistical methodology it was pos- sible to find the best arrangement between the amounts of the gallium heteroatom and the vanadium active species. The higher levels of the objective function were obtained employing the catalyst with 4 wt.% of gallium and 6 wt.% of vanadium; the optimal ratio between g DBT/g of catalyst was 4 and the molar ratio between H2O2/DBT was 5. Gallium incorporation as heteroatom in tetrahedral position allowed the better anchorage ofthe active species of vanadium, generating a very well dispersed catalyst. The optimized catalyst minimized the mass transfer limitation and moreover, was active after several recycles. The best catalyst was likewise very active for the oXidation of the most refractory sulfur compounds as benzothiophene and 4,6-dimetyldi- benzothiopene.Item HaP / LP-SBA-15 Nanocomposite for efficient removal of fluoride from contaminated wáter(2020) López, Claudia G.; Anunziata, Oscar A.; Cussa, JorgelinaHydroxyapatite (HaP) composites and highly ordered large pore mesoporous silica, such as LP-SBA-15 (Large Pore-SBA-15), were developed, characterized by XRD, BET, FTIR and HRTEM, and applied properly to fluoride removal from contaminated water. The proposed procedure to prepare HaP/LP-SBA-15 was successful, which acts as supports to anchor the HaP crystals, in nanometer-scale (<12 nm), with higher fluoride retention from contaminated water. The free OH- groups of HaP nanocrystals, inside the host, permitted fluoride retention with high capacity. The fluoride holding activity was over 3 orders of magnitude higher than pure HaP.Item Hidrogenación de tetralin utilizando un catalizador bifuncional de iridio/platino-SBA-15(2014) Vallés, Verónica; Ledesma, Brenda; Rivoira, Lorena Paola; Cussa, Jorgelina; Martínez, María Laura; Anunziata, Oscar Alfredo; Beltramone, Andrea RaquelLos catalizadores bimetálicos de Pt–Pd han recibido considerable atención debido a que demuestran tener una alta actividad en una amplia variedad de aplicaciones catalíticas (1). Con alta actividad, selectividad y estabilidad, comparada con catalizadores monometálicos de Pt y Pd. Por ejemplo, catalizadores bimetálicos Pt-Pd muestran tener mayor resistencia frente a envenenamientos en comparación con catalizadores de Pt (2-4). Las características estudiadas del catalizador serán correlacionadas con su performance catalítica en la hidrogenación del tetralin. El objetivo final es encontrar la proporción óptima de cada uno de los metales de forma de lograr la mayor actividad en dicho proceso.Item LP-SBA-15/ketorolac nanocomposite: development, characterization, and mathematical modeling of controlled keto release(2022) Cussa, Jorgelina; Juárez, Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar AlfredoDrug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the nanomaterial LP-SBA-15 as an attractive new host for drug delivery systems due to its high biocompatibility, in vivo biodegradability, and low toxicity. LP-SBA-15/Ketorolac was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release and achieving the required therapeutic efficacy. The host shows the ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release from the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, the Ritger-Peppas model followed by the Weibull model the best ones. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response.Item Mesoporous cellular foam (MCF): an efficient and biocompatible nanomaterial for the controlled release of chlorambucil(2022) Juárez, Juliana María; Cussa, Jorgelina; Anunziata, Oscar Alfredo; Gómez Costa, Marcos BrunoNanotransporters have entered a great deal of exploration attention because of their promising openings in medicine delivery. We propose in this work, the Mesostructured siliceous cellular (MCFs) nanomaterial as a promising new host for drug delivery systems because both their specific physicochemical properties, in addition to the high biocompatibility, biodegradability, and low toxicity, make them seductive for controlled medicine release operations. Chlorambucil, is used as a chemotherapy drug administered for treating some types of cancer, chronic lymphocytic leukemia, low-grade non- Hodgkin’s lymphoma, Hodgkin’s lymphoma and ovarian cancer. Chlorambucil-loaded Mesostructured cellular foam (MCF-CLB) was prepared and characterized by XRD, TEM, UV- Vis DRS, FTIR, and texture analysis determining the adsorption capacity and its release, achieving the required therapeutic efficacy. The release of the drug was conducted by simulating the physiological conditions to reproduce the conditions of the organism. The mechanism of drug release from the MCF-CLB host was evaluated. Different mathematical models were used to adjust the experimental data, the best model describing the phenomenon under study over the entire period is the Weibull model. The auspicious results we attained for the release of the drug using the new material. The main advantage of this release is that the rate of release is fast at the beginning and then gradually decreases until 24 h practically all the drug contained in the carrier is released (> 95%).Item Optimization of NOx selective catalytic reduction in presence of iso-butane and 02 using Fecontaining ZSM-11 zeolites by multivariate analysis.(Univesidsad Tecnológica Nacional, 2012) Cussa, Jorgelina; Beltramone, Andrea; Anunziata, OscarThe nitrogen oxides reduction is a problem that the environmental catalysis still tries to solve. Thus, for this problematic, the processes can be grouped in three general lines of work: minimization of the production of NOx; direct decomposition of NO to N2 + O2, and selective catalytic reduction (SCR). Fe-ZSM-5 has in recent times received much attention in catalysis research because of its promising activity in the decomposition or selective reduction of nitrous oxide. Fe-ZSM-11 zeolites, prepared by novel sol-gel process with Fe2+ and/or Fe3+ as active sites incorporated by reproducible post-synthesis methods were obtained. We reported the relationship between the catalytic activity and the nature of the active sites [1]. The experiment design - response surface methodology is used in this work to optimize the NOx selective catalytic reduction to N2 using the above cited catalyst. The main objective is to define the response surfaces, finding the best combination of different parameters in order to optimize the process, for this reason, the experiments design methodology was applied reducing the operation costs, achieving efficiency and effectiveness in the process. The application of this methodology leads us to a better understanding of the influence of the different factors such as: number and strength of the acid sites, Fe2+/Fe3+ relation, [NO3*] and [NO2*] adsorbed intermediates, the concerted reaction mechanism proposed in the previous work, and the effect of the reaction temperature and their interactions. The statistic model applied in this work is a powerful tool to interpret the overall process from the multivariate parameters. The goal of the present work would be to identify the key-factors to optimizing the best operation conditions and catalysts characteristics, which are responsible for the enhanced performance of Fe-zeolites and thereby to corroborate with even better catalyst formulations. According to the statistic methodology applied, the best operation conditions and catalysts characteristics can be identified, allowing us to re-design the catalyst to enhance the NOx conversion and N2 and CO2 selectivity at optimum reaction temperature.Item Preparation, characterization and mathematical modeling of keterolac release conteined in lpsba-15 host(2021) Cussa, Jorgelina; Juárez, Juliana M.; Gómez Costa, Marcos B.; Anunziata, Oscar A.Drug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the LP-SBA-15 nanomaterial as a promising new host for drug delivery systems because of its high biocompatibility, in vivo biodegradability, and low toxicity. Ketorolac-LP-SBA-15 was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release, achieving the required therapeutic efficacy. The host shows ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, being the Ritger-Peppas model followed by the Weibull model the best ones. In this work, we show a promising drug storage material for effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. Studies indicate that KETO was adsorbed on the channel surface of LP-SBA-15 without affecting the structure or chemical composition of KETO. Controlled drug delivery systems can achieve precise delivery at the time and place of destination, keeping the concentration of the drug at points in the body within the optimal range and below the toxicity threshold. The study also demonstrates the storage capacity and release properties of LPSBA- 15 containing KETO. The release of KETO contained in LP-SBA-15 can offer a significant improvement in the controlled release of the drug and the analgesic and anti-inflammatory effects, positively influenced, by the links formed between the host and drug molecules and by diffusion through the host porosity. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response.Item Simultaneous optimization of methane conversion and aromatic yields by catalytic activation with ethane over Zn-ZSM-11 zeolite: the influence of the Zn-loading factor(2011) Anunziata, Oscar Alfredo; Cussa, Jorgelina; Beltramone, Andrea RaquelExperiment design-response surface methodology (RSM) is used in this work to model and optimize two responses in the process of activation of methane (C1) using ethane (C2) as co-reactant into higher hydro- carbons, over Zn-containing zeolite catalysts. The application of this methodology provides insights into a more comprehensive understanding of the influence attributed to from the different factors. In this study we analyze the influence of the C1 molar fraction (C1/C1 + C2), the reaction temperature and the Zn-loading factors. The responses analyzed were as follows: Y1: C1 conversion (mol% C) and Y2: aromatic hydrocarbon yields (mol% C). The response surfaces were obtained with the Box–Behnken Design, finding the best combination between the reaction parameters that allowed optimizing the process. By applying the statistic methodology, the higher levels of the two objective functions, C1 conversion of 48.6 mol% C and aromatic yields of 47.2 mol% C, were obtained employing, a higher temperature, 0.2–0.4 molar frac- tion of C1 and the catalysts with a higher Zn2+ content.Item Síntesis y caracterización de SBA-3: a partir de una sal metalica(2014) Ponte, María Virginia; Martínez, María Laura; Cussa, Jorgelina; Anunziata, Oscar Alfredo; Beltramone, Andrea RaquelMateriales porosos bimodales son materiales que poseen poros de dos tamaños diferentes. En estos materiales, las superficies de los pequeños poros pueden interactuar con moléculas, mientras que grandes poros proporcionan rutas de alta velocidad para el transporte de moléculas de gas y líquidos. Estos materiales poseen numerosas aplicaciones potenciales como adsorbentes, tamices moleculares y soportes de catalíticos. En todos los casos, el área superficial y tamaño de poro de estos materiales son de fundamental importancia debido al hecho de que pequeños poros puede promover una interacción entre los materiales porosos y las moléculas huéspedes. En este trabajo, se sintetizan por primera vez materiales mesoporosos del tipo SBA-3 utilizando como fuente de silicio, una diferente al Tetaetilortosilicato (TEOS), una sal metálica como lo es el silicato de sodio. Los materiales sintetizados son caracterizados en primera instancia mediante XRD. El procedimiento empleado para la síntesis de los materiales mesoporosos del tipo SBA-3 es el que se detalla a continuación. Se preparan dos soluciones: Solución A) solución de silicato de sodio: se parte de sílica gel, el cual es disuelto en una solución de NaOH y solución B) Se disuelve el agente direccionante de estructura (Bromuro de cetiltrimetil amonio (CTAB)) en agua destilada acidificada con HCl. Una vez obtenidas las dos soluciones, la solución A es agregada a la solución B por medio de goteo bajo condiciones de agitación (400 rpm) y temperatura ambiente. Pasada una hora, el precipitado es filtrado, lavado con agua destilada y secado a 50ºC toda la noche. Posteriormente, el surfactante es eliminado por medio de calcinación no oxidativa con flujo de N2 con un caudal de 20 ml/min a 500ºC durante un periodo de 5 horas, seguido de calcinación oxidativa en mufla a 550 ºC en aire por 5 h, aumentando la temperatura con una rampa de 5ºC/min. La composición final de la síntesis original fue de SiO2:NaO:CTAB:HCl:H2O=1:1,2:0,13:32:86, y el material obtenido se denominó SBA-3(SG). El material obtenido fue caracterizado por la técnica de XRD. Los picos característicos correspondientes a los planos de difracción (1 0 0), (1 1 0) y (2 0 0) fueron observados. Espectroscopia FT-IR se utilizó para investigar la vibración de estiramiento T–O–T (T representa Si). Las bandas características de Si tetraédrico se encontraron a 1080 y 800 cm-1 las cuales son generalmente insensibles a la estructura.Item Síntesis y caracterización de un catalizador soportado iridio/platino-SBA-15 para su aplicación(2014) Vallés, Verónica; Ledesma, Brenda; Rivoira, Lorena Paola; Cussa, Jorgelina; Martínez, María Laura; Anunziata, Oscar Alfredo; Beltramone, Andrea RaquelEn el presente trabajo se estudió el efecto de la dispersión de metales nobles Ir y Pt y la interacción con el soporte SBA-15, relacionándolos con la actividad catalítica del catalizador en la reacción de hidrogenación del Tetralin utilizando un reactor Parr a 250°C y 15 atm. Con este objetivo se sintetizaron catalizadores Ir/Pt-SBA-15 modificados con distintos % de Ir y Pt. La mesoestructura del soporte SBA-15 le confiere una estabilidad térmica relativamente alta y el diámetro apropiado de poro permite convertir moléculas voluminosas como las presentes en los cortes de combustibles líquidos. El soporte fue preparado por el método de sol-gel. Para la obtencion del sitio catalitico se utilizó l método de impregnación incipiente. Se disuelven el Acetil acetonato de Iridio (IrAcAc) y el Acido cloroplatinico hidratado (H2PtCl6.H2O) en 50 ml de etanol a 50ºC con reflujo. Luego se agrega a la SBA-15 previamente pesada la solución y se lo lleva a un evaporador rotatorio a 60 ºC y 70 rpm hasta lograr evaporar todo el solvente. Luego se deja secando en estufa a 110 ºC por 24 h. Posteriormente es calcinado en mufla a 500 ºC por 5 horas, seguido de reducción con hidrógeno. El material fue caracterizado mediante difracción de rayos X (XRD), se puede observar que conserva la estructura mesoporosa a bajo ángulo, mientras que a alto ángulo se observan los índices de refracción característicos de Ir y Pt metálicos. También fueron caracterizados por XPS y TEM. La dispersión del Me fue calculada mediante quimisorción de H2 se obtuvieron partículas de iridio/Platino (d= 4,0-2.0 nm) homogéneamente disperso, con una dispersión de más del 60%. Se obtuvo unaItem Síntesis, caracterización y aplicación del nanomaterial lp-sba-15 en la liberación controlada de ketorolac trometamina(2020) Juárez, Juliana M.; Gómez Costa, Marcos B.; Cussa, JorgelinaLos sistemas controlados de administración de fármacos pueden mantener la concentración de medicamentos en los sitios exactos del cuerpo dentro del rango óptimo y por debajo del umbral de toxicidad, mejorando la eficacia terapéutica y reduciendo la toxicidad. El material LP-SBA-15 es un nuevo huésped prometedor para los sistemas de administración de fármacos debido a su alta biocompatibilidad, biodegradabilidad in vivo y baja toxicidad. Se sintetizó el composite ketorolac-trometamina/LP-SBA-15. La síntesis del material y la carga de ketorolac-trometamina en los poros LP-SBA-15 fue exitosa, como lo demuestran los análisis XRD, FTIR, TGA, TEM y análisis morfologicos. Obtuvimos resultados prometedores para la liberación controlada de fármacos utilizando el nuevo material. La aplicación de estos materiales en la liberación de KETO es innovadora, logrando una alta tasa de liberación inicial y luego manteniendo una liberación más lenta. Esto permite mantener la concentración del fármaco dentro del rango de eficacia terapéutica, siendo altamente aplicable para el tratamiento de enfermedades que necesitan una respuesta rápida.Item Sistema de liberación controlada de fármacos: espuma mesoporosa MCF-clorambucilo(2022) Juárez, Juliana M.; Cussa, Jorgelina; Anunziata, Oscar A.; Gómez Costa, Marcos BrunoLa espuma celular mesoestructurada (MCF) es un material prometedor para los sistemas de administración de fármacos dado a la alta biocompatibilidad, biodegradabilidad y baja toxicidad. Sus propiedades incluyen una gran área superficial, poro grande uniforme. En este trabajo, la espuma mesoporosa MCF fue sintetizada con éxito para su aplicación en nanotransportadores de fármacos, específicamente de Clorambucilo, obteniendo el composite MCF-CBL. La síntesis del material mesoporoso y el proceso de incorporación de Clorambucilo en los poros de la MCF fueron exitosos tal como se muestra en los análisis de XRD, FTIR, TEM y análisis de propiedades texturales. La liberación del fármaco se realizó simulando las condiciones fisiológicas para reproducir las condiciones del organismo. Se evaluó el mecanismo de liberación del fármaco en el hospedaje MCF-CLB. Se utilizaron diferentes modelos matemáticos para ajustar los datos experimentales, el mejor modelo que describe el fenómeno en estudio durante todo el período es el modelo de Weibull. Los resultados auspiciosos que obtuvimos para la liberación del fármaco utilizando el nuevo material, la principal ventaja de esta liberación es que la velocidad de liberación es rápida al inicio y luego disminuye gradualmente hasta que se liberan 24 h prácticamente todo el fármaco contenido en el portador. (> 95%).Item Sistema de liberación controlada de fármacos: espuma mesoporosa MCFClorambucilo(2022) Juárez, Juliana María; Cussa, Jorgelina; Gómez Costa, Marcos Bruno; Anunziata, Oscar A.;La espuma celular mesoestructurada (MCF) es un material prometedor para los sistemas de administración de fármacos dado a la alta biocompatibilidad, biodegradabilidad y baja toxicidad. Sus propiedades incluyen una gran área superficial, poro grande uniforme. En este trabajo, la espuma mesoporosa MCF fue sintetizada con éxito para su aplicación en nanotransportadores de fármacos, específicamente de Clorambucilo, obteniendo el composite MCFCBL. La síntesis del material mesoporoso y el proceso de incorporación de Clorambucilo en los poros de la MCF fueron exitosos tal como se muestra en los análisis de XRD, FTIR, TEM y análisis de propiedades texturales. La liberación del fármaco se realizó simulando las condiciones fisiológicas para reproducir las condiciones del organismo. Se evaluó el mecanismo de liberación del fármaco en el hospedaje MCFCLB. Se utilizaron diferentes modelos matemáticos para ajustar los datos experimentales, el mejor modelo que describe el fenómeno en estudio durante todo el período es el modelo de Weibull. Los resultados auspiciosos que obtuvimos para la liberación del fármaco utilizando el nuevo material, la principal ventaja de esta liberación es que la velocidad de liberación es rápida al inicio y luego disminuye gradualmente hasta que se liberan 24 h prácticamente todo el fármaco contenido en el portador. (> 95%).Item Synthesis and characterization of conducting polypyrrole/SBA-3 and polypyrrole/Na–AlSBA-3 composites(2012) Gómez Costa, Marcos Bruno; Juárez, Juliana; Martínez, María Laura; Beltramone, Andrea Raquel; Cussa, Jorgelina; Anunziata, Oscar AlfredoSi-SBA-3 and Na–AlSBA-3 materials were synthesized for application in the preparation of composites. Silica mesoporous materials were obtained following the sol–gel method and post-synthesis alumination. Pyrrole-saturated hosts were prepared by adsorption of pyrrole into the mesoporous materials. The adsorption/desorption of pyrrole was studied by FTIR. Molecules of pyrrole would be adsorbed through aromatic ring to the host. The polymerization technique was performed by oxidative way using different oxidizing agents, ammonium persulfate and ferric chloride, after pyrrole adsorption on both hosts. TG, FTIR, BET, XRD, SEM and TEM were used to characterize the resulting composites. These studies show that polypyrrole is generated inside the channel of the hosts; conductivity studies show that the composites exhibit conductivities at room temperature and in the range of 1 × 10—7 and 1 × 10—6 S cm—1 depending on the host and the oxidizing agents.Item Synthesis, characterization and application of mesoporous materials in the controlled release of ibuprofen(2020) Cussa, Jorgelina; Anunziata, Oscar A.Drug delivery systems consist of an active ingredient and a carrier system that can direct the release of the drug to the appropriate site and in the appropriate amount. The characteristics that these vehicles must meet are low toxicity, optimal properties for drug transport and release, and long half-life. Three mesoporous materials are reported in this work, the first one containing lattice aluminum; named Al-Si/SBA-3; the second one containing magnesium; named Mg-SBA-3, and the third one named LP-SBA-15. These materials were characterized by X-ray diffraction, resulting in hexagonal porous nanostructures, with lattice parameters of 3.63 nm for Al-Si/SBA-3 (without significant changes in the periodicity of the lattice). LP-SBA-15 is a novel large porous nanomaterial. It is encouraging the results of the application of these materials as host-transporters in the study of the modified release of Ibuprofen. LP-SBA-15 appears to be the most promising delivery system for IBU and its controlled release.Item Synthesis, characterization and catalytic performance of bimetallic Ir-Pt catalysts for tetralin hydrogenation(2014) Vallés, Verónica; Ledesma, Brenda; Rivoira, Lorena Paola; Cussa, Jorgelina; Martínez, María Laura; Anunziata, Oscar Alfredo; Beltramone, Andrea RaquelBimetallic Pt–Pd catalysts have received considerable attention, because they show high activity in a variety of catalytic applications (1) and stability compared with monometallic Pt or Pd catalysts. For instance, the bimetallic Pt–Pd catalysts have been shown to have higher resistance toward poisonscompared to Pt catalysts (2-4). For supported bimetallic clusters, the surface and bulk composition strongly depend on a series of parameters, for example, preparation procedures, metal–metal and metal–support interactions. The final goal is to find the optimal proportion of each metal in order to be more active in these processes.In this case a series of Ir and Pt modified SBA-15 were prepared by the consecutive wet impregnation method, with different content of each metal. The final catalysts were characterized by XRD, TEM and H2 chemisorption to study the effect of content of metal on the dispersion of iridium/platinum. The catalysts synthesized with similar percentage of both metal showed the best activity measured in tetralin hydrogenation. Platinum (Pt) and Iridium (Ir) nanoparticles were incorporated into SBA-15 support [1-4] by the wet co-impregnation method. The metal precursors were Iridium acetylacetonate and cloroplatinic acid. The samples were calcined at 500°C and previous to the catalytic test the samples were reduced by heating at 2°C/min to 450°C in a H2 stream for 5 h. Hereinafter this catalyst will be referred as Ir-Pt- SBA-15 (x), with x= 1-3. The catalytic activity was measured in a 4563Parr reactor, at 250°C, 15 atm of pressure of hydrogen and 360 rpm for tetralin hydrogenation (feed consisted in 50 mL of 5% v/v of tetralin (98.5% FLUKA) in Dodecane). The Pt-Ir-SBA-15 catalyst with 1 %wt. of each metals had the highest activity measured in tetralin hydrogenation at mild conditions. The good activity was correlated with higher Ir/Pt dispersion on SBA-15 mesostructured material used as support, as we seen by TEM and H2 Chemisorption, with higher active metal sites exposed to reactant. The Ir-Pt-SBA-15 activity is sufficiently high to envisage use in the final stages of a refinery process producing diesel fuel of high Cetane Number by hydrodearomatization.Item Tetralin hydrogenation and ring opening of decalin over Ir-Pt-SBA-15(2014) Vallés, Verónica; Rivoira, Lorena Paola; Ledesma, Brenda; Cussa, Jorgelina; Anunziata, Oscar Alfredo; Beltramone, Andrea RaquelA series of Ir and Pt modified SBA-15 were prepared by the consecutive wet impregnation method, with different content of each metal. The final catalysts were characterized by XRD, TEM and H2 chemisorption to study the effect of content of metal on the dispersion of iridium/platinum. The catalysts synthesized with similar percentage of both metals showed the best activity measured in tetralin hydrogenation and ring opening of decalin at mild conditions.