Nanostructured SBA-15 host applied in ketorolac tromethamine release system
Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Springer Science+Business Media
Abstract
The ordered mesoporous silica SBA-15
has been applied in studies of ketorolac
tromethamine adsorption andrelease. The SBA 15 materials with hexagonal and regular structure
were obtained using a triblock copolymer Pluronic
P123 as a template and TEOS as a silica source.
Ketorolac tromethamine was adsorbed into SBA 15 silica nanochan- nels using ethanol as solvent.
The physicochemical and textural properties of
SBA-15 and ketorolac tromethamine/ SBA-15
were characterized by X-ray diffraction, thermo gravimetric analysis, transmission electron
microscopy, fourier transform infrared
spectroscopy and BET surface studies. Drug
release was evaluated by soaking the loaded
silica mesoporous material into a solution of HCl (0.1
N) at initial time (0–2 h) and buffer pH 7 at high times
at 37 °C under continuous stirring. Oral
commercial Keto tablets (Dolten®
) and Keto
solution (Keto power) were study for the contrast.
Release studies were performed in order to
evaluate the required therapeutic efficacy. SBA 15 provides significant improvement in the
controlled release of ketor- olac tromethamine.
Description
Keywords
mesoporous silica SBA-15, ketorolac tromethamine, reléase system
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