Large pore SBA-15 functionalized as drug carrier of Cyclophosphamide.
Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
Univesidsad Tecnológica Nacional
Abstract
Controlled drug administration systems can keep the level of drugs in specific locations in the
organism with low toxicity and above the optimal level. We suggest the LP-SBA-15 material as an
auspicious new host for drug delivery systems because of its low toxicity high biocompatibility and in
vivo biodegradability. LP-SBA-15 materials were synthesized and functionalized using 0-15-30% of
tert-butylamine (TBA) and used as effective drug delivery systems.
The anticancer drug Cyclophosphamide (CP) is an alkylating compound which is a phosphoramide
derivative and is habitually used in autoimmune diseases. Reactive oxygen species production has
been related to the mechanism of CP-induced cell death or tumor cell killing. The activated
metabolites of CP are released in both healthy and tumor tissues and destroy the cellular DNA and
proteins as well as mitochondrial and lysosomal membranes. CP was loaded into the nanomaterial of
the transporters and characterized by N2 adsorption-desorption, Ultraviolet-visible diffusereflectance
spectroscopy (UV-Vis DRS), FTIR, determining the adsorption capacity and its release.
The release of the drug was studied for each material by simulating the physiological conditions and
submerging the composite, at 37 °C with constant stirring, in a HCl solution (0.1 M) for the first two
hours and in Buffer solution pH = 7 the following hours to simulate the conditions of the organism.
Release experiments were conducted to determine the requisite efficacy of treatment. The study was
performed by UV-Vis spectrophotometry to evaluate the amount of CP released. The mechanism of
drug release from the LP-SBA-15 functionalized matrix was evaluated by adjusting the experimental
data, being the Ritger-Peppas model, Weibull model and First-Order model, the best models to adjust
the experimental data is the, which is confirmed by the R2 coefficient of determination.
The promising results we obtained for the controlled release of the drug in a controlled manner using
the new material, reaching a quick initial release rate and maintaining a constant rate at high moments,
allow us to keep the concentration of the drug in the therapeutic efficacy range, applying itto a great
extent to the treatment of diseases that require a rapid response. Lastly, it was suggested thatthe LP SBA-15 nanomaterial functionalized with 15% TBA was the most desirable system due to they had
adequate amounts of both drug loading and release
Description
Keywords
LP-SBA-15, Tert-butylamine, Cyclophosphamide, Nanostructured, Host, Drug delivering device, Nanoscale medicine
Citation
12th International Conference on Advanced Materials and Engineering Materials 2023.
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