LP-SBA-15, functionalized with tert-butylamine a novel controlled release system for cyclophosphamide.
Date
2013
Journal Title
Journal ISSN
Volume Title
Publisher
Univesidsad Tecnológica Nacional
Abstract
Controlled drug administration systems can keep the level of drugs in specific
locations in the organism with low toxicity and above the optimal level. We suggest
the LP-SBA-15 material as an auspicious new host for drug delivery systems
because of its low toxicity high biocompatibility and in vivo biodegradability. LP SBA-15 materials were synthesized and functionalized using 0-15-30% of tert butylamine (TBA) and used as effective drug delivery systems.
The anticancer drug Cyclophosphamide (CP) is an alkylating compound which is a
phosphoramide derivative and is habitually used in autoimmune diseases. Reactive
oxygen species production has been related to the mechanism of CP-induced cell
death or tumor cell killing. The activated metabolites of CP are released in both
healthy and tumor tissues and destroy the cellular DNA and proteins as well as
mitochondrial and lysosomal membranes. CP was loaded into the nanomaterial of
the transporters and characterized by XRD, FTIR, TGA, TEM and texture,
determining the adsorption capacity and its release.
The release of the drug was studied for each material by simulating the
physiological conditions and submerging the composite, at 37 °C with constant
stirring, in a HCl solution (0.1 M) for the first two hours and in Buffer solution pH = 7
the following hours to simulate the conditions of the organism.
Release experiment were conducted to determine the requisite efficacy of
treatment. The study was performed by UV-Vis spectrophotometry to evaluate the
amount of CP released. The mechanism of drug release from the LP-SBA-15 matrix
was evaluated by adjusting the experimental data, being the Ritger-Peppas (figure
1)
The promising results we obtained for the controlled release of the drug in a
controlled manner using the new material, reaching a quick initial release rate and
maintaining a constant rate at high moments, allow us to keep the concentration of
the drug in the therapeutic efficacy range, applying it to a great extent to the
treatment of diseases that require a rapid response. Lastly, it was suggested that
the LP-SBA-15 nanomaterial functionalized with 15% TBA was the most desirable
system due to they had adequate amounts of both drug loading and release
Description
Keywords
LP-SBA-15, Tert-Butylamine, Cyclophosphamide, Nanostructured host, Drug delivering device, Nanoscale medicine
Citation
Smart Materials and Surfaces 2013.
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