UTN- FRC -Producción Académica de Investigación y Desarrollo
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Item HaP/SBA-3 Nanostructured Composite to Remove Fluoride Effectively from Contaminated Water.(Univesidsad Tecnológica Nacional, 2021) Cussa, Jorgelina; López , Claudia; Anunziata, Oscar Alfredo; Anunziata, Oscar AlfredoHighly ordered pore mesoporous silica composites, like SBA-3 and hydroxyapatite (HaP) nanocrystals, characterized by X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and textural properties, were successfully applied to remove fluoride from contaminated water. The proposed procedure to prepare HaP/SBA-3 wassuccessful, which acts as supports to anchor the HaP crystals, in nanometer-scale (<2nm), with higher fluoride retention from contaminated water. The free OH- groups of HaP nanocrystals, within the host, facilitated the high-performance fluoride trapping. The fluoride retention activity was much higher than that of pure HaP and the composites HaP/SBA-15 and HaP/MCM-41.Item Large pore SBA-15 functionalized as drug carrier of Cyclophosphamide.(Univesidsad Tecnológica Nacional, 2023) Juárez , Juliana María; Cussa, Jorgelina; Anunziata, Oscar Alfredo; Gómez Costa, Marcos BrunoControlled drug administration systems can keep the level of drugs in specific locations in the organism with low toxicity and above the optimal level. We suggest the LP-SBA-15 material as an auspicious new host for drug delivery systems because of its low toxicity high biocompatibility and in vivo biodegradability. LP-SBA-15 materials were synthesized and functionalized using 0-15-30% of tert-butylamine (TBA) and used as effective drug delivery systems. The anticancer drug Cyclophosphamide (CP) is an alkylating compound which is a phosphoramide derivative and is habitually used in autoimmune diseases. Reactive oxygen species production has been related to the mechanism of CP-induced cell death or tumor cell killing. The activated metabolites of CP are released in both healthy and tumor tissues and destroy the cellular DNA and proteins as well as mitochondrial and lysosomal membranes. CP was loaded into the nanomaterial of the transporters and characterized by N2 adsorption-desorption, Ultraviolet-visible diffusereflectance spectroscopy (UV-Vis DRS), FTIR, determining the adsorption capacity and its release. The release of the drug was studied for each material by simulating the physiological conditions and submerging the composite, at 37 °C with constant stirring, in a HCl solution (0.1 M) for the first two hours and in Buffer solution pH = 7 the following hours to simulate the conditions of the organism. Release experiments were conducted to determine the requisite efficacy of treatment. The study was performed by UV-Vis spectrophotometry to evaluate the amount of CP released. The mechanism of drug release from the LP-SBA-15 functionalized matrix was evaluated by adjusting the experimental data, being the Ritger-Peppas model, Weibull model and First-Order model, the best models to adjust the experimental data is the, which is confirmed by the R2 coefficient of determination. The promising results we obtained for the controlled release of the drug in a controlled manner using the new material, reaching a quick initial release rate and maintaining a constant rate at high moments, allow us to keep the concentration of the drug in the therapeutic efficacy range, applying itto a great extent to the treatment of diseases that require a rapid response. Lastly, it was suggested thatthe LP SBA-15 nanomaterial functionalized with 15% TBA was the most desirable system due to they had adequate amounts of both drug loading and releaseItem LP-SBA-15-TBA-CP: Tert-Butylamine and Cyclophosphamide detailed study by FTIR and 3D structure.(Univesidsad Tecnológica Nacional, 2023) Anunziata , Oscar Alfredo; Cussa, JorgelinaA careful study of the vibrational spectra of the host (LP-SBA-15), functionalizing agent, tert-Butylamine (TBA), and N, N-bis(2-chloroethyl)tetrahydro-2H-1,3,2- oxazaphosphorin-2-amine 2-oxide, cyclophosphamide (CP) was performed, as there is a diversity of assignments published by different authors [1-5]. Our preliminary OM studies (AM1, PM3, Density Functional Theory, application of the Fukui function), and extensive FTIR studies, we estimated the binding energies, bond lengths and bond angles of CP as well as for TBA-CP, leading us to suggest that CP is embedded in an ellipsoid.Item Efficient retention of fluorides using SBA-3mesoporous Material.(Univesidsad Tecnológica Nacional, 2022) Cussa, Jorgelina; López , Claudia; Anunziata, Oscar Alfredo; Anunziata, Oscar AlfredoHighly ordered pore mesoporous silica composites, like SBA-3 and hydroxyapatite (HaP) nanocrystals, characterized by X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and textural properties, were successfully applied to remove fluoride from contaminated water. The proposed procedure to prepare HaP/SBA-3 was successful, which acts as supports to anchor the HaP crystals, in nanometer-scale (<2 nm), with higher fluoride retention from contaminated water. The free OH- groups of HaP nanocrystals, within the host, facilitated the high-performance fluoride trapping. The fluoride retention activity was much higher than that of pure HaP and the composites HaP/SBA-15 and HaP/MCM-41.Item Drug delivery system: large pore SBA-15 as host for ketorolac tromethamine(2022) Juárez, Juliana María; Cussa, Jorgelina; Anunziata, Oscar Alfredo; Gómez Costa, Marcos BrunoDrug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the LP-SBA-15 nanomaterial as a promising new host for drug delivery systems because of its high biocompatibility, in vivo biodegradability, and low toxicity. Ketorolac-LP-SBA-15 was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release, achieving the required therapeutic efficacy. The host shows ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, being the Ritger-Peppas model followed by the Weibull model the best ones. In this work, we show a promising drug storage material for effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. Studies indicate that KETO was adsorbed on the channel surface of LP-SBA-15 without affecting the structure or chemical composition of KETO. Controlled drug delivery systems can achieve precise delivery at the time and place of destination, keeping the concentration of the drug at points in the body within the optimal range and below the toxicity threshold. The study also demonstrates the storage capacity and release properties of LPSBA-15 containing KETO. The release of KETO contained in LP-SBA-15 can offer a significant improvement in the controlled release of the drug and the analgesic and anti-inflammatory effects, positively influenced, by the links formed between the host and drug molecules and by diffusion through the host porosity. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response.Item Sistema de liberación controlada de fármacos: espuma mesoporosa MCF-clorambucilo(2022) Juárez, Juliana M.; Cussa, Jorgelina; Anunziata, Oscar A.; Gómez Costa, Marcos BrunoLa espuma celular mesoestructurada (MCF) es un material prometedor para los sistemas de administración de fármacos dado a la alta biocompatibilidad, biodegradabilidad y baja toxicidad. Sus propiedades incluyen una gran área superficial, poro grande uniforme. En este trabajo, la espuma mesoporosa MCF fue sintetizada con éxito para su aplicación en nanotransportadores de fármacos, específicamente de Clorambucilo, obteniendo el composite MCF-CBL. La síntesis del material mesoporoso y el proceso de incorporación de Clorambucilo en los poros de la MCF fueron exitosos tal como se muestra en los análisis de XRD, FTIR, TEM y análisis de propiedades texturales. La liberación del fármaco se realizó simulando las condiciones fisiológicas para reproducir las condiciones del organismo. Se evaluó el mecanismo de liberación del fármaco en el hospedaje MCF-CLB. Se utilizaron diferentes modelos matemáticos para ajustar los datos experimentales, el mejor modelo que describe el fenómeno en estudio durante todo el período es el modelo de Weibull. Los resultados auspiciosos que obtuvimos para la liberación del fármaco utilizando el nuevo material, la principal ventaja de esta liberación es que la velocidad de liberación es rápida al inicio y luego disminuye gradualmente hasta que se liberan 24 h prácticamente todo el fármaco contenido en el portador. (> 95%).Item Controlled drug release system: MCF-Chlorambucil mesoporous foam(2022) Juárez, Juliana M.; Cussa, Jorgelina; Anunziata, Oscar Alfredo; Goméz Costa, Marcos BrunoMesostructured cellular foam (MCF) is a promising material for drug delivery systems due to its high biocompatibi0lity, biodegradability, and low toxicity. Its properties include a large surface area, uniform large pore. In this work, the MCF mesoporous foam was successfully synthesized for its application in drug nanocarriers, specifically Chlorambucil, obtaining the MCF-CLB composite. The synthesis of the mesoporous material and the process of incorporation of Chlorambucil in the pores of the MCF were successful as shown in the XRD, UV Vis Ref. Difusa, TEM analysis and analysis of textural properties. The release of the drug was conducted by simulating the physiological conditions to reproduce the conditions of the organism. The mechanism of drug release from the MCF-CLB host was evaluated. Different mathematical models were used to adjust the experimental data, the best model describing the phenomenon under study over the entire period is the Weibull model. The auspicious results we attained for the release of the drug using the new material, the main advantage of this release is that the rate of release is fast at the beginning and then gradually decreases until 24 h practically all the drug contained in the carrier is released (>95%).Item LP-SBA-15/ketorolac nanocomposite: development, characterization, and mathematical modeling of controlled keto release(2022) Cussa, Jorgelina; Juárez, Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar AlfredoDrug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the nanomaterial LP-SBA-15 as an attractive new host for drug delivery systems due to its high biocompatibility, in vivo biodegradability, and low toxicity. LP-SBA-15/Ketorolac was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release and achieving the required therapeutic efficacy. The host shows the ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release from the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, the Ritger-Peppas model followed by the Weibull model the best ones. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response.Item Mesoporous cellular foam (MCF): an efficient and biocompatible nanomaterial for the controlled release of chlorambucil(2022) Juárez, Juliana María; Cussa, Jorgelina; Anunziata, Oscar Alfredo; Gómez Costa, Marcos BrunoNanotransporters have entered a great deal of exploration attention because of their promising openings in medicine delivery. We propose in this work, the Mesostructured siliceous cellular (MCFs) nanomaterial as a promising new host for drug delivery systems because both their specific physicochemical properties, in addition to the high biocompatibility, biodegradability, and low toxicity, make them seductive for controlled medicine release operations. Chlorambucil, is used as a chemotherapy drug administered for treating some types of cancer, chronic lymphocytic leukemia, low-grade non- Hodgkin’s lymphoma, Hodgkin’s lymphoma and ovarian cancer. Chlorambucil-loaded Mesostructured cellular foam (MCF-CLB) was prepared and characterized by XRD, TEM, UV- Vis DRS, FTIR, and texture analysis determining the adsorption capacity and its release, achieving the required therapeutic efficacy. The release of the drug was conducted by simulating the physiological conditions to reproduce the conditions of the organism. The mechanism of drug release from the MCF-CLB host was evaluated. Different mathematical models were used to adjust the experimental data, the best model describing the phenomenon under study over the entire period is the Weibull model. The auspicious results we attained for the release of the drug using the new material. The main advantage of this release is that the rate of release is fast at the beginning and then gradually decreases until 24 h practically all the drug contained in the carrier is released (> 95%).Item EXperimental design optimization of the ODS of DBT using vanadium oXide supported on mesoporous Ga-SBA-15(2020) Rivoira, Lorena Paola; Cussa, Jorgelina; Martínez, María Laura; Beltramone, Andrea RaquelEXperiment design-response surface methodology is applied in this work to model and optimize the o Xidation of dibenzothiophene (DBT) using VOX-Ga-SBA-15 catalyst. The analyzed variables are the influence of the nature of the catalyst (V and Ga loading), the s ubstrate/catalyst mass ratio (g DBT/g of catalyst) and the o Xidant/substrate molar ratio (H2O2/DBT). The response analyzed is conversion of DBT at 15 min of reaction time. A set of re- sponse surfaces were obtained applying the BoX-Behnken Design. Based on statistical methodology it was pos- sible to find the best arrangement between the amounts of the gallium heteroatom and the vanadium active species. The higher levels of the objective function were obtained employing the catalyst with 4 wt.% of gallium and 6 wt.% of vanadium; the optimal ratio between g DBT/g of catalyst was 4 and the molar ratio between H2O2/DBT was 5. Gallium incorporation as heteroatom in tetrahedral position allowed the better anchorage ofthe active species of vanadium, generating a very well dispersed catalyst. The optimized catalyst minimized the mass transfer limitation and moreover, was active after several recycles. The best catalyst was likewise very active for the oXidation of the most refractory sulfur compounds as benzothiophene and 4,6-dimetyldi- benzothiopene.