Synthesis and encapsulation of bis-eugenol in a mesoporous solid material: Enhancement of the antioxidant activity of a natural compound from Clove Oil.
Guntero, Vanina A.
Ferreti, Cristián A.
Mancini, Pedro M. E.
Kneeteman, María N.
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In the present work, microwave extraction conditions to recover high eugenol content in the crude extract from clove were investigated. The effect of factors like temperature, stirring, time, liquid: Solid ratio and solutions of solvent were evaluated with Taguchi’s method. The eugenol content was determined by gas chromatography. From the isolated eugenol, the bis-phenol was synthesized by the dimerization of eugenol. The encapsulation of bis-eugenol on the mesoporous silica was carried out by a microwave assisted process. Previously, mesoporous silica SBA-15 was prepared by hydrothermal synthesis using Pluronic P123 triblock copolymer as a surfactant. The bis-eugenol encapsulated in SBA-15 was characterized by physicochemical techniques. The results indicated that the encapsulation of bis-eugenol in the pores of silica occurred through weak interactions of an electrostatic nature without producing chemical changes in the antioxidant property. The antioxidative activity of eugenol, bis-eugenol and bis-eugenol/SBA-15 system was examined by phosphomolybdenum assay. Among these materials, a remarkably high antioxidant activity was found in bis-eugenol encapsulated in SBA-15. These resultas suggest the possibility of applying this system as an antioxidant active packaging in the future.
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