Facultad Regional Córdoba

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Author: search.filters.author.Cussa, Jorgelina

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    HaP/SBA-3 Nanostructured Composite to Remove Fluoride Effectively from Contaminated Water.
    (Univesidsad Tecnológica Nacional, 2021) Cussa, Jorgelina; López , Claudia; Anunziata, Oscar Alfredo; Anunziata, Oscar Alfredo
    Highly ordered pore mesoporous silica composites, like SBA-3 and hydroxyapatite (HaP) nanocrystals, characterized by X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and textural properties, were successfully applied to remove fluoride from contaminated water. The proposed procedure to prepare HaP/SBA-3 wassuccessful, which acts as supports to anchor the HaP crystals, in nanometer-scale (<2nm), with higher fluoride retention from contaminated water. The free OH- groups of HaP nanocrystals, within the host, facilitated the high-performance fluoride trapping. The fluoride retention activity was much higher than that of pure HaP and the composites HaP/SBA-15 and HaP/MCM-41.
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    Optimization of the synthesis of SBA-3 mesoporous materials by experimental design
    (Elsevier Inc., 2016-02-18) Ponte, María Virignia; Rivoira, Lorena Paola; Cussa, Jorgelina; Martínez, Maria Laura; Beltramone, Andrea Raquel; Anunziata, Oscar Alfredo
    SBA-3 mesoporous materials are characterized by hexagonal regular arrangements of channels with diameters >2 nm, high specific surface areas and high specific pore volumes. In the work reported herein, experimental design-response surface methodology (RSM) is used to model and optimize the synthesis conditions for SBA-3 mesoporous materials. In this study, we evaluate the influences of surfactant/silica source molar ratios, aging times, temperature and pH on the synthesis of SBA-3 mesoporous materials by analyzing the XRD intensities pertaining to the [100] signal. Response surfaces were obtained using the BoxeBehnken design, and the combination of reaction parameters was optimized. By applying statistical methodology, higher levels of the objective function (XRD intensities pertaining to the [100] signal) were obtained using cetyltrimethylammonium bromide (CTAB)/tetraethyl orthosilicate (TEOS) molar ratios of 0.07 and 0.16, HCl/TEOS molar ratios of 8 and 11, reaction temperatures of 35 and 45 ◦C and aging times of 12e24 h. The mesoporous SBA-3 samples obtained were characterized using small-angle X-ray powder diffraction (XRD), BET, FTIR and 29Si NMR-MAS, scanning electron microscopy (SEM) and transmission electron microscopy (TEM).
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    Nanostructured SBA-15 host applied in ketorolac tromethamine release system
    (Springer Science+Business Media, 2017) Cussa, Jorgelina; Juárez, Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfreco
    The ordered mesoporous silica SBA-15 has been applied in studies of ketorolac tromethamine adsorption andrelease. The SBA 15 materials with hexagonal and regular structure were obtained using a triblock copolymer Pluronic P123 as a template and TEOS as a silica source. Ketorolac tromethamine was adsorbed into SBA 15 silica nanochan- nels using ethanol as solvent. The physicochemical and textural properties of SBA-15 and ketorolac tromethamine/ SBA-15 were characterized by X-ray diffraction, thermo gravimetric analysis, transmission electron microscopy, fourier transform infrared spectroscopy and BET surface studies. Drug release was evaluated by soaking the loaded silica mesoporous material into a solution of HCl (0.1 N) at initial time (0–2 h) and buffer pH 7 at high times at 37 °C under continuous stirring. Oral commercial Keto tablets (Dolten® ) and Keto solution (Keto power) were study for the contrast. Release studies were performed in order to evaluate the required therapeutic efficacy. SBA 15 provides significant improvement in the controlled release of ketor- olac tromethamine.
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    LP-SBA-15, functionalized with tert-butylamine a novel controlled release system for cyclophosphamide.
    (Univesidsad Tecnológica Nacional, 2013) Juárez , Juliana María; Cussa, Jorgelina; Gómez costa , Marcos Bruno; Anunziata, Oscar Alfredo; Anunziata, Oscar Alfredo
    Controlled drug administration systems can keep the level of drugs in specific locations in the organism with low toxicity and above the optimal level. We suggest the LP-SBA-15 material as an auspicious new host for drug delivery systems because of its low toxicity high biocompatibility and in vivo biodegradability. LP SBA-15 materials were synthesized and functionalized using 0-15-30% of tert butylamine (TBA) and used as effective drug delivery systems. The anticancer drug Cyclophosphamide (CP) is an alkylating compound which is a phosphoramide derivative and is habitually used in autoimmune diseases. Reactive oxygen species production has been related to the mechanism of CP-induced cell death or tumor cell killing. The activated metabolites of CP are released in both healthy and tumor tissues and destroy the cellular DNA and proteins as well as mitochondrial and lysosomal membranes. CP was loaded into the nanomaterial of the transporters and characterized by XRD, FTIR, TGA, TEM and texture, determining the adsorption capacity and its release. The release of the drug was studied for each material by simulating the physiological conditions and submerging the composite, at 37 °C with constant stirring, in a HCl solution (0.1 M) for the first two hours and in Buffer solution pH = 7 the following hours to simulate the conditions of the organism. Release experiment were conducted to determine the requisite efficacy of treatment. The study was performed by UV-Vis spectrophotometry to evaluate the amount of CP released. The mechanism of drug release from the LP-SBA-15 matrix was evaluated by adjusting the experimental data, being the Ritger-Peppas (figure 1) The promising results we obtained for the controlled release of the drug in a controlled manner using the new material, reaching a quick initial release rate and maintaining a constant rate at high moments, allow us to keep the concentration of the drug in the therapeutic efficacy range, applying it to a great extent to the treatment of diseases that require a rapid response. Lastly, it was suggested that the LP-SBA-15 nanomaterial functionalized with 15% TBA was the most desirable system due to they had adequate amounts of both drug loading and release
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    Large pore SBA-15 functionalized as drug carrier of Cyclophosphamide.
    (Univesidsad Tecnológica Nacional, 2023) Juárez , Juliana María; Cussa, Jorgelina; Anunziata, Oscar Alfredo; Gómez Costa, Marcos Bruno
    Controlled drug administration systems can keep the level of drugs in specific locations in the organism with low toxicity and above the optimal level. We suggest the LP-SBA-15 material as an auspicious new host for drug delivery systems because of its low toxicity high biocompatibility and in vivo biodegradability. LP-SBA-15 materials were synthesized and functionalized using 0-15-30% of tert-butylamine (TBA) and used as effective drug delivery systems. The anticancer drug Cyclophosphamide (CP) is an alkylating compound which is a phosphoramide derivative and is habitually used in autoimmune diseases. Reactive oxygen species production has been related to the mechanism of CP-induced cell death or tumor cell killing. The activated metabolites of CP are released in both healthy and tumor tissues and destroy the cellular DNA and proteins as well as mitochondrial and lysosomal membranes. CP was loaded into the nanomaterial of the transporters and characterized by N2 adsorption-desorption, Ultraviolet-visible diffusereflectance spectroscopy (UV-Vis DRS), FTIR, determining the adsorption capacity and its release. The release of the drug was studied for each material by simulating the physiological conditions and submerging the composite, at 37 °C with constant stirring, in a HCl solution (0.1 M) for the first two hours and in Buffer solution pH = 7 the following hours to simulate the conditions of the organism. Release experiments were conducted to determine the requisite efficacy of treatment. The study was performed by UV-Vis spectrophotometry to evaluate the amount of CP released. The mechanism of drug release from the LP-SBA-15 functionalized matrix was evaluated by adjusting the experimental data, being the Ritger-Peppas model, Weibull model and First-Order model, the best models to adjust the experimental data is the, which is confirmed by the R2 coefficient of determination. The promising results we obtained for the controlled release of the drug in a controlled manner using the new material, reaching a quick initial release rate and maintaining a constant rate at high moments, allow us to keep the concentration of the drug in the therapeutic efficacy range, applying itto a great extent to the treatment of diseases that require a rapid response. Lastly, it was suggested thatthe LP SBA-15 nanomaterial functionalized with 15% TBA was the most desirable system due to they had adequate amounts of both drug loading and release
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    LP-SBA-15-TBA-CP: Tert-Butylamine and Cyclophosphamide detailed study by FTIR and 3D structure.
    (Univesidsad Tecnológica Nacional, 2023) Anunziata , Oscar Alfredo; Cussa, Jorgelina
    A careful study of the vibrational spectra of the host (LP-SBA-15), functionalizing agent, tert-Butylamine (TBA), and N, N-bis(2-chloroethyl)tetrahydro-2H-1,3,2- oxazaphosphorin-2-amine 2-oxide, cyclophosphamide (CP) was performed, as there is a diversity of assignments published by different authors [1-5]. Our preliminary OM studies (AM1, PM3, Density Functional Theory, application of the Fukui function), and extensive FTIR studies, we estimated the binding energies, bond lengths and bond angles of CP as well as for TBA-CP, leading us to suggest that CP is embedded in an ellipsoid.
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    Efficient retention of fluorides using SBA-3mesoporous Material.
    (Univesidsad Tecnológica Nacional, 2022) Cussa, Jorgelina; López , Claudia; Anunziata, Oscar Alfredo; Anunziata, Oscar Alfredo
    Highly ordered pore mesoporous silica composites, like SBA-3 and hydroxyapatite (HaP) nanocrystals, characterized by X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and textural properties, were successfully applied to remove fluoride from contaminated water. The proposed procedure to prepare HaP/SBA-3 was successful, which acts as supports to anchor the HaP crystals, in nanometer-scale (<2 nm), with higher fluoride retention from contaminated water. The free OH- groups of HaP nanocrystals, within the host, facilitated the high-performance fluoride trapping. The fluoride retention activity was much higher than that of pure HaP and the composites HaP/SBA-15 and HaP/MCM-41.
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    Optimization of NOx selective catalytic reduction in presence of iso-butane and 02 using Fecontaining ZSM-11 zeolites by multivariate analysis.
    (Univesidsad Tecnológica Nacional, 2012) Cussa, Jorgelina; Beltramone, Andrea; Anunziata, Oscar
    The nitrogen oxides reduction is a problem that the environmental catalysis still tries to solve. Thus, for this problematic, the processes can be grouped in three general lines of work: minimization of the production of NOx; direct decomposition of NO to N2 + O2, and selective catalytic reduction (SCR). Fe-ZSM-5 has in recent times received much attention in catalysis research because of its promising activity in the decomposition or selective reduction of nitrous oxide. Fe-ZSM-11 zeolites, prepared by novel sol-gel process with Fe2+ and/or Fe3+ as active sites incorporated by reproducible post-synthesis methods were obtained. We reported the relationship between the catalytic activity and the nature of the active sites [1]. The experiment design - response surface methodology is used in this work to optimize the NOx selective catalytic reduction to N2 using the above cited catalyst. The main objective is to define the response surfaces, finding the best combination of different parameters in order to optimize the process, for this reason, the experiments design methodology was applied reducing the operation costs, achieving efficiency and effectiveness in the process. The application of this methodology leads us to a better understanding of the influence of the different factors such as: number and strength of the acid sites, Fe2+/Fe3+ relation, [NO3*] and [NO2*] adsorbed intermediates, the concerted reaction mechanism proposed in the previous work, and the effect of the reaction temperature and their interactions. The statistic model applied in this work is a powerful tool to interpret the overall process from the multivariate parameters. The goal of the present work would be to identify the key-factors to optimizing the best operation conditions and catalysts characteristics, which are responsible for the enhanced performance of Fe-zeolites and thereby to corroborate with even better catalyst formulations. According to the statistic methodology applied, the best operation conditions and catalysts characteristics can be identified, allowing us to re-design the catalyst to enhance the NOx conversion and N2 and CO2 selectivity at optimum reaction temperature.
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    Drug delivery system: large pore SBA-15 as host for ketorolac tromethamine
    (2022) Juárez, Juliana María; Cussa, Jorgelina; Anunziata, Oscar Alfredo; Gómez Costa, Marcos Bruno
    Drug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the LP-SBA-15 nanomaterial as a promising new host for drug delivery systems because of its high biocompatibility, in vivo biodegradability, and low toxicity. Ketorolac-LP-SBA-15 was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release, achieving the required therapeutic efficacy. The host shows ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, being the Ritger-Peppas model followed by the Weibull model the best ones. In this work, we show a promising drug storage material for effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. Studies indicate that KETO was adsorbed on the channel surface of LP-SBA-15 without affecting the structure or chemical composition of KETO. Controlled drug delivery systems can achieve precise delivery at the time and place of destination, keeping the concentration of the drug at points in the body within the optimal range and below the toxicity threshold. The study also demonstrates the storage capacity and release properties of LPSBA-15 containing KETO. The release of KETO contained in LP-SBA-15 can offer a significant improvement in the controlled release of the drug and the analgesic and anti-inflammatory effects, positively influenced, by the links formed between the host and drug molecules and by diffusion through the host porosity. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response.
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    Sistema de liberación controlada de fármacos: espuma mesoporosa MCF-clorambucilo
    (2022) Juárez, Juliana M.; Cussa, Jorgelina; Anunziata, Oscar A.; Gómez Costa, Marcos Bruno
    La espuma celular mesoestructurada (MCF) es un material prometedor para los sistemas de administración de fármacos dado a la alta biocompatibilidad, biodegradabilidad y baja toxicidad. Sus propiedades incluyen una gran área superficial, poro grande uniforme. En este trabajo, la espuma mesoporosa MCF fue sintetizada con éxito para su aplicación en nanotransportadores de fármacos, específicamente de Clorambucilo, obteniendo el composite MCF-CBL. La síntesis del material mesoporoso y el proceso de incorporación de Clorambucilo en los poros de la MCF fueron exitosos tal como se muestra en los análisis de XRD, FTIR, TEM y análisis de propiedades texturales. La liberación del fármaco se realizó simulando las condiciones fisiológicas para reproducir las condiciones del organismo. Se evaluó el mecanismo de liberación del fármaco en el hospedaje MCF-CLB. Se utilizaron diferentes modelos matemáticos para ajustar los datos experimentales, el mejor modelo que describe el fenómeno en estudio durante todo el período es el modelo de Weibull. Los resultados auspiciosos que obtuvimos para la liberación del fármaco utilizando el nuevo material, la principal ventaja de esta liberación es que la velocidad de liberación es rápida al inicio y luego disminuye gradualmente hasta que se liberan 24 h prácticamente todo el fármaco contenido en el portador. (> 95%).