Desarrollo, Producción e Innovación en la Investigación científica

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Author: search.filters.author.Gómez Costa, Marcos BrunoSubject: search.filters.subject.Chlorambucil

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    Mesoporous Cellular Foam (MCF): an efcient and biocompatible nanomaterial for the controlled release of Chlorambucil.
    (Univesidsad Tecnológica Nacional, 2022) Juárez , Juliana María; Cussa , jorgelina; Gómez Costa, Marcos Bruno
    Nanotransporters have entered a great deal of exploration attention because of their promising openings in medicine delivery. We propose in this work, the Mesostructured siliceous cellular (MCFs) nanomaterial as a promising new hostfor drug delivery systems because both their specific physicochemical properties, in addition to the high biocompatibility, biodegradability, and low toxicity, make them seductive for controlled medicine release operations. Chlorambucil, is used as a chemotherapy drug administered for treating some types of cancer, chronic lymphocytic leukemia, low-grade non Hodgkin’s lymphoma, Hodgkin’s lymphoma and ovarian cancer. Chlorambucil-loaded Mesostructured cellular foam (MCF-CLB) was prepared and characterized by XRD, TEM, UV Vis DRS, FTIR, and texture analysis determining the adsorption capacity and its release, achieving the required therapeutic efficacy. The release of the drug was conducted by simulating the physiological conditions to reproduce the conditions of the organism. The mechanism of drug release from the MCF-CLB host was evaluated. Different mathematical models were used to adjust the experimental data, the best model describing the phenomenon under study over the entire period is the Weibull model. The auspicious results we attained for the release of the drug using the new material. The main advantage of this release is that the rate of release is fast at the beginning and then gradually decreases until 24 h practically all the drug contained in the carrier is released (>95%).
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    Controlled drug release system: MCF-Chlorambucil mesoporous foam.
    (Univesidsad Tecnológica Nacional, 2022) Júarez , Juliana María; Cussa , Jorgelina; Anunziata, Oscar Alfredo; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo
    Mesostructured cellular foam (MCF) is a promising material for drug delivery systems due to its high biocompatibi0lity, biodegradability, and low toxicity. Its properties include a large surface area, uniform large pore. In this work, the MCF mesoporous foam was successfully synthesized for its application in drug nanocarriers, specifically Chlorambucil, obtaining the MCF-CLB composite. The synthesis of the mesoporous material and the process of incorporation of Chlorambucil in the pores of the MCF were successful as shown in the XRD, UV Vis Ref. Difusa, TEM analysis and analysis of textural properties. The release of the drug was conducted by simulating the physiological conditions to reproduce the conditions of the organism. The mechanism of drug release from the MCF-CLB host was evaluated. Different mathematical models were used to adjust the experimental data, the best model describing the phenomenon under study over the entire period is the Weibull model. The auspicious results we attained for the release of the drug using the new material, the main advantage of this release is that the rate of release is fast at the beginning and then gradually decreases until 24 h practically all the drug contained in the carrier is released (>95%).
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    Drug release system: Chlorambucil loaded in mesoporous cellular foam (MCF)
    (2022) Juárez, Juliana María; Anunziata, Oscar Alfredo; Gómez Costa, Marcos Bruno
    Nanotransporters have received a great deal of research attention because of their promising opportunities in drug delivery [1-5]. Attempting to minimize the secondary adverse events of anticancer drugs and enhance the therapeutic rate, various nanotransporters have been devised, including dendrimers [6, 7], liposomes [8, 9], inorganic nanoparticles, and polymeric nanoparticles [10-13]. Chlorambucil (CLB), is a substance classified as a human carcinogen [14], it is used as a chemotherapy drug administered for treating some types of cancer. It is mainly used to treat chronic lymphocytic leukemia, low-grade nonHodgkin's lymphoma, Hodgkin's lymphoma and ovarian cancer. Chemically, it is 4-[4-bis(2-chloroethyl) amino phenyl butyric acid. MCFs (mesostructured siliceous cellular foams), that can be derived after the inclusion of a bulking medium in the synthesis procedure of SBA-15 [4], are composed of spherically uniform cells 15-50 nm diameter [15], exhibit high surface areas and porosities, and have adjustable pore size distributions [15, 16]. The open large pore system gives MCF unique advantages as catalyst support and separation media for processes involving large molecules. In addition to their specific physicochemical properties, they possess high biocompatibility and low adverse effects, which with their biodegradability, making them attractive for controlled drug release applications.