Mesoporous Cellular Foam (MCF): an efcient and biocompatible nanomaterial for the controlled release of Chlorambucil.
Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Univesidsad Tecnológica Nacional
Abstract
Nanotransporters have entered a great deal of exploration attention because of their promising openings in medicine delivery.
We propose in this work, the Mesostructured siliceous cellular (MCFs) nanomaterial as a promising new hostfor drug
delivery systems because both their specific physicochemical properties, in addition to the high biocompatibility,
biodegradability, and low toxicity, make them seductive for controlled medicine release operations. Chlorambucil, is used
as a chemotherapy drug administered for treating some types of cancer, chronic lymphocytic leukemia, low-grade non Hodgkin’s lymphoma, Hodgkin’s lymphoma and ovarian cancer.
Chlorambucil-loaded Mesostructured cellular foam (MCF-CLB) was prepared and characterized by XRD, TEM, UV Vis DRS, FTIR, and texture analysis determining the adsorption capacity and its release, achieving the required therapeutic
efficacy.
The release of the drug was conducted by simulating the physiological conditions to reproduce the conditions of the
organism. The mechanism of drug release from the MCF-CLB host was evaluated. Different mathematical models were used
to adjust the experimental data, the best model describing the phenomenon under study over the entire period is the Weibull
model. The auspicious results we attained for the release of the drug using the new material. The main advantage of this
release is that the rate of release is fast at the beginning and then gradually decreases until 24 h practically all the drug
contained in the carrier is released (>95%).
Description
Keywords
MCF, Chlorambucil, Nanotransporters, Drug delivering device, Nanoscale medicine
Citation
Journal of porous materials.(Accepted: 5 may 2022 the author(s), under exclusive licence to springer science+business media,LLC, part of springer nature 2022 )
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