Ketorolac-tromethamine contained in SBA-15 host as a drug release system,
Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Univesidsad Tecnológica Nacional
Abstract
Drug delivery is an emerging field mainly focused on targeting drugs. The goal of this targeted
delivery is to transport an amount of drugs to desirable sites (such as tumors and diseased tissues)
while minimizing unwanted side effects of the drugs on other tissues[1]. Controlled drug delivery
systems can achieve precise spatial and temporal delivery of therapeutic agents to the target site[2].
The ordered mesoporous silica SBA-15 has been applied in studies of ketorolac tromethamine
adsorption and release. The SBA-15 materials with hexagonal and regular structure were obtained
using a triblock copolymer Pluronic P123 as a template and TEOS as a silica source[3]. Ketorolac
tromethamine was adsorbed into SBA-15 silica nanochannels using ethanol as solvent. The
physicochemical and textural properties of SBA-15 and ketorolac tromethamine/SBA-15 were
characterized by X-ray diffraction, thermogravimetric analysis, transmission electron microscopy, Fourier
transform infrared spectroscopy and BET surface studies. Drug release was evaluated by soaking the
loaded silica mesoporous material into a solution of HCl (0.1N) at initial time (0 - 2 h) and buffer pH
7 at high times at 37 ºC under continuous stirring. Oral commercial Keto tablets
(Dolten®) and Keto solution (Keto power) were study for the contrast. Release studies were performed
in order to evaluate the required therapeutic efficacy. In this work, we have shown a promising drug
storage material for the effective encapsulation and controlled release of KETO, achieving the required
therapeutic efficacy. SBA-15/KETO shows characteristic bands of both, drug materials and the inorganic
framework. This indicates that KETO was adsorbed into SBA-15 channel surface without affecting the
chemical structure or composition of KETO. The study also demonstrates the storage capacity and
release properties of SBA-15 containing KETO. The release of KETO contained in SBA-15 can offer
significant improve in controlled drug release and enhance a good analgesia effect.
Description
Keywords
SBA-15, Ketorolac tromethamine, Nanostructured Composite
Citation
XXV International Materials Research Congress.
Endorsement
Review
Supplemented By
Referenced By
Creative Commons license
Except where otherwised noted, this item's license is described as info:eu-repo/semantics/openAccess