Ordered mesoporous SBA-15 host for Ketorolac-Tromethamine loading and release behavior.

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Date

2017

Authors

Cussa , jorgelina
Juárez , Juliana María
Gómez Costa , Marcos Bruno
Anunziata , Oscar Alfredo
Anunziata , Oscar Alfredo
Juárez , Juliana María

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Univesidsad Tecnológica Nacional

Abstract

The ordered mesoporous silica SBA-15 has been applied in studies of ketorolac tromethamine adsorption and release. The SBA-15 materials with hexagonal and regular structure were obtained using a triblock copolymer Pluronic P123 as a template and TEOS as a silica source. Ketorolac tromethamine was adsorbed into SBA-15 silica nanochannels using ethanol as solvent. The physicochemical and textural properties of SBA-15 and ketorolac tromethamine/SBA-15 were characterized by X-ray diffraction, thermogravimetric analysis, transmission electron microscopy, Fourier transform infrared spectroscopy and BET surface studies. The composite SBA-15/KETO shows characteristic bands of both, drug materials and the inorganic framework. This indicates that KETO was adsorbed into SBA-15 channel surface without affecting the chemical structure or composition of KETO. Drug release was evaluated by soaking the loaded silica mesoporous material into a solution of HCl (0.1N) at initial time (0 - 2 h) and buffer pH 7 at high times at 37 ºC under continuous stirring. Oral commercial Keto tablets (Dolten®) and Keto solution (Keto power) were study for the contrast. Release studies were performed in order to evaluate the required therapeutic efficacy. SBA-15 provides significant improvement in the controlled release of ketorolac tromethamine and enhance a good analgesia effect.

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Keywords

SBA-15, Ketorolac tromethamine, Drug release

Citation

20th Intenational Conference on Surface Modification of Materials by beams (SMMIB-2017) 09th to 14st july 2017 Instituto Superior Técnico.

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