Ordered mesoporous SBA-15 host for Ketorolac-Tromethamine loading and release behavior.
Date
2017
Authors
Cussa , jorgelina
Juárez , Juliana María
Gómez Costa , Marcos Bruno
Anunziata , Oscar Alfredo
Anunziata , Oscar Alfredo
Juárez , Juliana María
Journal Title
Journal ISSN
Volume Title
Publisher
Univesidsad Tecnológica Nacional
Abstract
The ordered mesoporous silica SBA-15 has been applied in studies of ketorolac tromethamine
adsorption and release. The SBA-15 materials with hexagonal and regular structure were obtained
using a triblock copolymer Pluronic P123 as a template and TEOS as a silica source. Ketorolac
tromethamine was adsorbed into SBA-15 silica nanochannels using ethanol as solvent. The
physicochemical and textural properties of SBA-15 and ketorolac tromethamine/SBA-15 were
characterized by X-ray diffraction, thermogravimetric analysis, transmission electron microscopy,
Fourier transform infrared spectroscopy and BET surface studies. The composite SBA-15/KETO
shows characteristic bands of both, drug materials and the inorganic framework. This indicates that
KETO was adsorbed into SBA-15 channel surface without affecting the chemical structure or
composition of KETO. Drug release was evaluated by soaking the loaded silica mesoporous material
into a solution of HCl (0.1N) at initial time (0 - 2 h) and buffer pH 7 at high times at 37 ºC under
continuous stirring. Oral commercial Keto tablets (Dolten®) and Keto solution (Keto power) were
study for the contrast. Release studies were performed in order to evaluate the required therapeutic
efficacy. SBA-15 provides significant improvement in the controlled release of ketorolac
tromethamine and enhance a good analgesia effect.
Description
Keywords
SBA-15, Ketorolac tromethamine, Drug release
Citation
20th Intenational Conference on Surface Modification of Materials by beams (SMMIB-2017) 09th to 14st july 2017 Instituto Superior Técnico.
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