Desarrollo, Producción e Innovación en la Investigación científica
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Item H2 storage using Zr-CMK-3 developed by a new synthesis method.(Univesidsad Tecnológica Nacional, 2021) Juárez , Juliana María; Venosta , Lisandro; Anunziata, Oscar Alfredo; Gómez Costa , Marcos Bruno; Anunziata, Oscar AlfredoOne of the biggest problems in using hydrogen as an alternative fuel is that its storage must be safe and portable. This work addresses a new direct synthesis technique used to obtain a novel mesoporous carbon (CMK-3) modified with zirconium oxide. This novel material shows promise for hydrogen adsorption and storage application for energy harvesting. Zirconium oxide (Zr-CMK-3) material is achieved through successful synthesis and characterized by XRD, SEM,Raman, BET, UV-Vis-DRS, XPS and TEM analyses. Zr-CMK-3 signifi- cantly improved H2 storage performance (reaching at 77 K and 10 bar 4.6 wt%) comparedto the pristine CMK-3. The novel material is favorable for H2 uptake by using weak bonding (physisorption). A hydrogen uptake mechanistic approach is proposed and the role of the Zr+4 cation in hydrogen adsorption is discussed.Item LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release.(Univesidsad Tecnológica Nacional, 2023) Cussa, jorgelina; Juárez , Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar AlfredoDrug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the nanomaterial LP-SBA-15 as an attractive new host for drug delivery systems due to its high biocompatibility, in vivo biodegradability, and low toxicity. LP-SBA-15/Ketorolac was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release and achieving the required therapeutic efficacy. The host shows the ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release from the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, the Ritger-Peppas model followed by the Weibull model the best ones. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response.Item HaP/SBA-3 Nanostructured Composite to Remove Fluoride Effectively from Contaminated Water.(Univesidsad Tecnológica Nacional, 2021) Cussa, Jorgelina; López , Claudia; Anunziata, Oscar Alfredo; Anunziata, Oscar AlfredoHighly ordered pore mesoporous silica composites, like SBA-3 and hydroxyapatite (HaP) nanocrystals, characterized by X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and textural properties, were successfully applied to remove fluoride from contaminated water. The proposed procedure to prepare HaP/SBA-3 wassuccessful, which acts as supports to anchor the HaP crystals, in nanometer-scale (<2nm), with higher fluoride retention from contaminated water. The free OH- groups of HaP nanocrystals, within the host, facilitated the high-performance fluoride trapping. The fluoride retention activity was much higher than that of pure HaP and the composites HaP/SBA-15 and HaP/MCM-41.Item The humanization of chemical species. "Path to the hidden reality".(Univesidsad Tecnológica Nacional, 2023) Anunziata, Oscar AlfredoThis work is multidisciplinary and brings together aspects of Quantum Physic chemistry, Physics, Chemistry and Epistemology/Semiotics. By exploring topics ranging from materials to design, it alsoseeks to elucidate the underlying connections between the natural (visible reality) and the artificial (hidden reality), and experiment and modeling. The results are intended to contain elements of discovery and surprise that often accompany the gainingof new knowledge toward a new conception of the architecture and function of the mass of matter and energy that sustains our thoughts. We conceive of Reality as everything that is detected by our senses, and especially that which is visible to our eyes, or which, aided by the development of high-tech equipment, we can detect. Nevertheless, isthis reality the only one? This conception does not explain phenomena that occur in the Cosmological Nature, so my proposal is that other "Hidden" realities exist but we do not detect them, or that they simply do not exist. After "humanizing" (giving the attribution of thinking, responding, acting), to species that we do not conceive to have "Life" such as atoms, to cite one, every particle that makes up the mass of matter andenergy of the Universe led me to the "creation of a New chemical species" (C-Zr-SO4H2), recently reported1 . This attribution ascribed to mass/energetic species, without neural systems, led me after three years toconceive the Idea of Hidden Reality and to generate a possible mechanism (architecture), of how we think when our objective is to hit an “invisible target”, or to "create" new targets. Abstraction. The symbolic abstraction (inscrutable variables). Abstract Symbolism (parameterization of abstract variables). Symbolic Reality (expression of mass of matter or energy indefinite, but symbolized).Real Symbolism (parameterization of functional variables that replicate the Hidden Reality). From HiddenReality to Detectable Reality.Item SYNTHESIS OF g-C3N4/METAL-SBA-15 COMPOSITE: STUDY OF THE INFLUENCE OF THE DIFFERENT METALS ANCHORED IN THE SUPPORT.(Univesidsad Tecnológica Nacional, 2023) Martínez , María Laura; Parreño Romero , Miriam; Anunziata, Oscar Alfredo; Domine, MarceloCarbon nitride (g-C3N4) polymers have garnered considerable attention from the environmental and energy sectors due to their low cost, low toxicity, unique structural and physicochemical properties, and their high physical and chemical stability; they find application as catalysts, as electrodes, as optoelectronic materials, etc. These materials primarily composed of carbon and nitrogen can be synthesized using various methods, but thermal polymerization employing low-cost raw materials containing carbon and nitrogen predominates. This study synthesized g-C3N4 supported Metal-SBA-15 mesoporous materials by evaluating the effect of metal on g-C3N4 formation. Carbon nitrides were synthesized using urea through the thermal polymerization method. Various supported carbon nitrides on mesoporous materials from the Si-based SBA-15 family were prepared. Additionally, a series of materials containing Ga, Al, Sn, and Zr anchored on SBA-15 (with Si/Metal ratio of 20) were tested. The attained g-C3N4/Metal-SBA-15 composites were characterized by XRD, ICP, EA, HR-TEM, SEM-EDX, and N2 adsorption isotherms, among others. To explore the chemical structure of the composites, the chemical bonds existing within the g-C3N4 structure were investigated by FT-IR spectroscopy. The FT-IR spectra of g-C3N4 samples, displayed characteristic peaks at 810 cm-1, 1410 cm-1, 1645 cm-1, and 3100– 3300 cm-1, which describe bending modes characteristic of the out-of-plane tri-units of triazine and C=N, stretching vibrations typical of the C=N and C–N bonds of aromatic CN heterocycles, and the stretching mode of the N‒H bond of non-condensed terminal amino groups, respectively. While SBA-15 material without metal did not exhibit absorption bands characteristic of a g-C3N4, Ga-SBA-15 and Zr-SBA-15 materials exhibited weak absorption bands in the region of 1100 and 1700 cm-1. Interestingly, materials containing aluminum and tin not only exhibited the characteristic bands of SBA-15 but also added the typical bands of g-C3N4. These results, also confirmed by other analysis, revealed that the g-C3N4 chemical structure was efficiently supported onto the metal-containing mesoporous materials. To complete the study, carbon nitride materials were attempted to be synthesized with sulfated zirconia/SBA-15 at different Si/Metal ratios. The results obtained were promising, thus allowing proving the positive effect of S species on the g-C3N4 formation.Item Large pore SBA-15 functionalized as drug carrier of Cyclophosphamide.(Univesidsad Tecnológica Nacional, 2023) Juárez , Juliana María; Cussa, Jorgelina; Anunziata, Oscar Alfredo; Gómez Costa, Marcos BrunoControlled drug administration systems can keep the level of drugs in specific locations in the organism with low toxicity and above the optimal level. We suggest the LP-SBA-15 material as an auspicious new host for drug delivery systems because of its low toxicity high biocompatibility and in vivo biodegradability. LP-SBA-15 materials were synthesized and functionalized using 0-15-30% of tert-butylamine (TBA) and used as effective drug delivery systems. The anticancer drug Cyclophosphamide (CP) is an alkylating compound which is a phosphoramide derivative and is habitually used in autoimmune diseases. Reactive oxygen species production has been related to the mechanism of CP-induced cell death or tumor cell killing. The activated metabolites of CP are released in both healthy and tumor tissues and destroy the cellular DNA and proteins as well as mitochondrial and lysosomal membranes. CP was loaded into the nanomaterial of the transporters and characterized by N2 adsorption-desorption, Ultraviolet-visible diffusereflectance spectroscopy (UV-Vis DRS), FTIR, determining the adsorption capacity and its release. The release of the drug was studied for each material by simulating the physiological conditions and submerging the composite, at 37 °C with constant stirring, in a HCl solution (0.1 M) for the first two hours and in Buffer solution pH = 7 the following hours to simulate the conditions of the organism. Release experiments were conducted to determine the requisite efficacy of treatment. The study was performed by UV-Vis spectrophotometry to evaluate the amount of CP released. The mechanism of drug release from the LP-SBA-15 functionalized matrix was evaluated by adjusting the experimental data, being the Ritger-Peppas model, Weibull model and First-Order model, the best models to adjust the experimental data is the, which is confirmed by the R2 coefficient of determination. The promising results we obtained for the controlled release of the drug in a controlled manner using the new material, reaching a quick initial release rate and maintaining a constant rate at high moments, allow us to keep the concentration of the drug in the therapeutic efficacy range, applying itto a great extent to the treatment of diseases that require a rapid response. Lastly, it was suggested thatthe LP SBA-15 nanomaterial functionalized with 15% TBA was the most desirable system due to they had adequate amounts of both drug loading and releaseItem Efficient retention of fluorides using SBA-3mesoporous Material.(Univesidsad Tecnológica Nacional, 2022) Cussa, Jorgelina; López , Claudia; Anunziata, Oscar Alfredo; Anunziata, Oscar AlfredoHighly ordered pore mesoporous silica composites, like SBA-3 and hydroxyapatite (HaP) nanocrystals, characterized by X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and textural properties, were successfully applied to remove fluoride from contaminated water. The proposed procedure to prepare HaP/SBA-3 was successful, which acts as supports to anchor the HaP crystals, in nanometer-scale (<2 nm), with higher fluoride retention from contaminated water. The free OH- groups of HaP nanocrystals, within the host, facilitated the high-performance fluoride trapping. The fluoride retention activity was much higher than that of pure HaP and the composites HaP/SBA-15 and HaP/MCM-41.Item The humanization of chemical species "Path to the hidden reality"(Univesidsad Tecnológica Nacional, 2022) Anunziata, Oscar AlfredoThis work is multidisciplinary and brings together aspects of Quantum Physic chemistry, Physics, Chemistry and Epistemology/Semiotics. By exploring topics ranging from materials to design, it also seeks to elucidate the underlying connections between the natural (visible reality) and the artificial (hidden reality), and experiment and modeling. The results are intended to contain elements of discovery and surprise that often accompany the gaining of new knowledge toward a new conception of the architecture and function of the mass of matter and energy that sustains our thoughts. We conceive of Reality as everything that is detected by our senses, and especially that which is visible to our eyes, or which, aided by the development of high-tech equipment, we can detect. Nevertheless, is this reality the only one? This conception does not explain phenomena that occur in the Cosmological Nature, so my proposal is that other "Hidden" realities exist but we do not detect them, or that they simply do not exist. We can create and verify them, as scientists have been doing for centuries. Logically, the strategies (architecture) of our thoughts must differ a lot to reach them, with respect to the proven reality. This vision is far from violating the feeling of "Faith". When we trust a person and his actions, it is because we have faith in him. How can we not have faith in God, in Christ, or in any confession that we all have as human being? After "humanizing" (giving the attribution of thinking, responding, acting), to species that we do not conceive to have "Life" such as atoms, to cite one, every particle that makes up the mass of matter and energy of the Universe led me to the "creation of a New chemical species" (C-Zr-SO4H2), recently reported 1 . The humanization of chemical species took me years, and the dialogues, just as an example with one of the atomic or subatomic chemical species was: “Hello Zirconia, I come to propose a new type of relationship to link with other atoms; I am not willing to get out of my stability; I understand, I wouldn't either, but listen. Would you be able to help me by sharing two electrons with two more atoms? Not even crazy, a charge fraction, never, or one or two electrons yes, what you propose to me no! It would take me out of my emotional and bodily stability and it would destroy me....Wait, I need you as an isolated entity, as an atom, not as rust; no way!!!. I understand how oxide you are very stable and you lead a pleasant life, but if to compensate for this fraction of negative charge, I generate a link relationship with an atom that offers a huge electronic screen, and it will have no problem sharing with you the fraction you lack to have a net negative charge No!!! Look, here is the sulfate species, they are already known, and they form stable species, he is willing to share with you the 0.33 that you are missing; what do you say, what do you feel? Oh, yes, with that enormous electronic screen and with my friend Sulfate, it is something else, but how would it be? You would have two shared electrons with two carbon atoms (two electrons between three atoms, 0.66 net negative charge for each atom). Since the C (graphite phase) has four shared electrons forming a C=C double bond, with which they would share their two free electrons, remaining with two electrons forming a simple and stable C-C bond, and the missing fraction you would share with Sulfate. Moreover, where do you want to go? In my deep abstraction, after having used several times the door between the real and the invisible, I am convinced that I can generate, without betraying any of my relations with you (C, Zr, O, Sulfate), a novel specie C-Zr-SO4, with properties that you will be very proud to offer to Nature. Ok, okay, let's try it, but if in the meantime of the synthesis I feel the slightest physical or mental disturbance, I'll go with the oxygen and we will form zirconium oxide, stable and without alterations”. I had these dialogues, similar or different, with the Carbon atoms and the Sulfate ion. It was not easy, try to ask non-captive questions, with more than one answer possibility. While I was building them, at the beginning, I wrote, but since I crossed out everything the next day, I decided to keep them in my memory, after an exhaustive study of the mass and electronic nature of each atomic or subatomic particle. The strategy for me was clear, I have to put myself in the other's place, try to feel and respond as if I were the other, except that the other was not a human being. Nevertheless, as I tried to "humanize" them, the upcoming was fascinating for me. As a consequence of our work in the laboratory, we generated the special conditions to form this new species (or at least they were in my Symbolic Abstraction), we characterized it, we purified it and “EUREKA”, we obtained it and it is now described in the work already cited. This attribution ascribed to mass/energetic species, without neural systems (first probable inconsistency), led me after three years to conceive the Idea of Hidden Reality and to generate a possible mechanism (architecture), of how we think when our objective is to hit an “invisible target”, or to "create" new targets. Thus, using my constructs in the Hard Sciences and Epistemology and Semiotics, I have arrived at the hypothesis of the next suggestion of the mechanism of thought toward the occult reality. The synaptic energy goes from greater to lesser as we advance in the mechanism. In that sense, it is possible to start in the order described or not. My suggestion is to follow the order, as you will see below.Item Controlled drug release system: MCF-Chlorambucil mesoporous foam.(Univesidsad Tecnológica Nacional, 2022) Júarez , Juliana María; Cussa , Jorgelina; Anunziata, Oscar Alfredo; Gómez Costa, Marcos Bruno; Anunziata, Oscar AlfredoMesostructured cellular foam (MCF) is a promising material for drug delivery systems due to its high biocompatibi0lity, biodegradability, and low toxicity. Its properties include a large surface area, uniform large pore. In this work, the MCF mesoporous foam was successfully synthesized for its application in drug nanocarriers, specifically Chlorambucil, obtaining the MCF-CLB composite. The synthesis of the mesoporous material and the process of incorporation of Chlorambucil in the pores of the MCF were successful as shown in the XRD, UV Vis Ref. Difusa, TEM analysis and analysis of textural properties. The release of the drug was conducted by simulating the physiological conditions to reproduce the conditions of the organism. The mechanism of drug release from the MCF-CLB host was evaluated. Different mathematical models were used to adjust the experimental data, the best model describing the phenomenon under study over the entire period is the Weibull model. The auspicious results we attained for the release of the drug using the new material, the main advantage of this release is that the rate of release is fast at the beginning and then gradually decreases until 24 h practically all the drug contained in the carrier is released (>95%).Item Major challenges for Nanoscience and Nanotechnology in Health for sustainability.(Univesidsad Tecnológica Nacional, 2022) Anunziata, Oscar AlfredoThis paper covers the physicochemical basis of studies of the structure and properties of inorganic and organic nanomaterials, advances in synthesis, processing, characterization and testing, design of Nano engineered materials and systems, and applications in technology, focusing on working atoms to individual atoms, anchored, deposited or grafted onto Carbon nanotubes and Mesoporous Carbons
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