LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release.
Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
Univesidsad Tecnológica Nacional
Abstract
Drug-controlled release systems can keep the level of drugs in precise doses in the body
above the optimal level and with low toxicity. We propose the nanomaterial LP-SBA-15 as an attractive
new host for drug delivery systems due to its high biocompatibility, in vivo biodegradability, and low
toxicity. LP-SBA-15/Ketorolac was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM,
and texture analysis, determining the adsorption capacity and its release and achieving the required
therapeutic efficacy. The host shows the ordered mesoporous nanochannels with a diameter of 11-12
nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release from the
LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental
data, the Ritger-Peppas model followed by the Weibull model the best ones. The promising results we
obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release
rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the
therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response.
Description
Keywords
LP-SBA-15, Ketorolac tromethamine, Nanostructured host, Drug-delivering device, Nanoscale medicine
Citation
Biointerface Research in Chemistry 2023.
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