LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release.

dc.creatorCussa, jorgelina
dc.creatorJuárez , Juliana María
dc.creatorGómez Costa, Marcos Bruno
dc.creatorAnunziata, Oscar Alfredo
dc.date.accessioned2025-03-13T19:18:49Z
dc.date.issued2023
dc.description.abstractDrug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the nanomaterial LP-SBA-15 as an attractive new host for drug delivery systems due to its high biocompatibility, in vivo biodegradability, and low toxicity. LP-SBA-15/Ketorolac was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release and achieving the required therapeutic efficacy. The host shows the ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release from the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, the Ritger-Peppas model followed by the Weibull model the best ones. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response.
dc.description.affiliationFil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
dc.description.affiliationFil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
dc.description.affiliationFil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
dc.description.affiliationFil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
dc.formatpdf
dc.identifier.citationBiointerface Research in Chemistry 2023.
dc.identifier.issn2069-5837
dc.identifier.urihttp://hdl.handle.net/20.500.12272/12382
dc.language.isoen
dc.publisherUnivesidsad Tecnológica Nacional
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.holderCussa, Jorgelina; Juárez, Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo.
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.usehttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectLP-SBA-15
dc.subjectKetorolac tromethamine
dc.subjectNanostructured host
dc.subjectDrug-delivering device
dc.subjectNanoscale medicine
dc.titleLP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release.
dc.typeinfo:eu-repo/semantics/article
dc.type.versionacceptedVersion

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