LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release.
dc.creator | Cussa, jorgelina | |
dc.creator | Juárez , Juliana María | |
dc.creator | Gómez Costa, Marcos Bruno | |
dc.creator | Anunziata, Oscar Alfredo | |
dc.date.accessioned | 2025-03-13T19:18:49Z | |
dc.date.issued | 2023 | |
dc.description.abstract | Drug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the nanomaterial LP-SBA-15 as an attractive new host for drug delivery systems due to its high biocompatibility, in vivo biodegradability, and low toxicity. LP-SBA-15/Ketorolac was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release and achieving the required therapeutic efficacy. The host shows the ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release from the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, the Ritger-Peppas model followed by the Weibull model the best ones. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response. | |
dc.description.affiliation | Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina. | |
dc.description.affiliation | Fil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina. | |
dc.description.affiliation | Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina. | |
dc.description.affiliation | Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina. | |
dc.format | ||
dc.identifier.citation | Biointerface Research in Chemistry 2023. | |
dc.identifier.issn | 2069-5837 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12272/12382 | |
dc.language.iso | en | |
dc.publisher | Univesidsad Tecnológica Nacional | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.holder | Cussa, Jorgelina; Juárez, Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo. | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.rights.use | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | LP-SBA-15 | |
dc.subject | Ketorolac tromethamine | |
dc.subject | Nanostructured host | |
dc.subject | Drug-delivering device | |
dc.subject | Nanoscale medicine | |
dc.title | LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release. | |
dc.type | info:eu-repo/semantics/article | |
dc.type.version | acceptedVersion |
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