Synthesis, characterization of nanoporous SBA-15 host and application in Ketorolac-Tromethamine release system.
Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Univesidsad Tecnológica Nacional
Abstract
Controlled release technologies are growing in
importance in modern medication and pharmaceutical
industries. Drug delivery is an emerging field mainly
focused on targeting drugs. The goal of this targeted
delivery is to transport an amount of drugs to desirable
sites (such as tumors and diseased tissues) while
minimizing unwanted side effects of the drugs on other
tissues [1]. Generally, controlled drug delivery systems
can maintain the concentration of drugs in the precise
sites of the body within the optimum range and under
the toxicity threshold, improving therapeutic efficacy
and reducing toxicity [2]. Nanotechnology will
produce significant results; hence, the drug is
controlled during days or even weeks, depending on
the disease that needs to be treated.
In recent years mesoporous silicas have been used for
hosting and further delivery of various biomolecules
and drugs [3]. SBA-15 is a crystalline mesoporous
molecular framework with an ordered and precise
mesoporous hexagonally system. This material shows
uniform channels and a pore diameter that can be
varied systematically between 1.5 and 10 nm with
surfactant as the template, auxiliary chemicals and
reaction conditions. Ketorolac tromethamine (KETO)
is a pyrrolizine carboxylic acid derivative of NSAIDs
with potent analgesic and moderate anti-inflammatory
activity; it is a relatively favorable therapeutic agent
for the treatment of moderate to severe pain. The main
goal of this study is the adsorption capacity and
storage properties of SBA-15/ KETO release in
achieving the required therapeutic efficacy
Description
Keywords
Nanoporous SBA-15, Ketorolac-Tromethamine, Controled reléase technology
Citation
18th International Zeolite Conference.
Endorsement
Review
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