Synthesis, characterization of nanoporous SBA-15 host and application in Ketorolac-Tromethamine release system.

Abstract

Controlled release technologies are growing in importance in modern medication and pharmaceutical industries. Drug delivery is an emerging field mainly focused on targeting drugs. The goal of this targeted delivery is to transport an amount of drugs to desirable sites (such as tumors and diseased tissues) while minimizing unwanted side effects of the drugs on other tissues [1]. Generally, controlled drug delivery systems can maintain the concentration of drugs in the precise sites of the body within the optimum range and under the toxicity threshold, improving therapeutic efficacy and reducing toxicity [2]. Nanotechnology will produce significant results; hence, the drug is controlled during days or even weeks, depending on the disease that needs to be treated. In recent years mesoporous silicas have been used for hosting and further delivery of various biomolecules and drugs [3]. SBA-15 is a crystalline mesoporous molecular framework with an ordered and precise mesoporous hexagonally system. This material shows uniform channels and a pore diameter that can be varied systematically between 1.5 and 10 nm with surfactant as the template, auxiliary chemicals and reaction conditions. Ketorolac tromethamine (KETO) is a pyrrolizine carboxylic acid derivative of NSAIDs with potent analgesic and moderate anti-inflammatory activity; it is a relatively favorable therapeutic agent for the treatment of moderate to severe pain. The main goal of this study is the adsorption capacity and storage properties of SBA-15/ KETO release in achieving the required therapeutic efficacy