UTN- FRC -Producción Académica de Investigación y Desarrollo - Artículos
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Item Nanoalambres de poliindol contenidos en hospedajes silíceos SBA-15 y Al- SBA-15 con distintas propiedades conductoras(Sociedad Argentina de Catálisis, 2015) Juárez , Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar AlfredoLos materiales nanoestructurados Si-SBA-15 y AlSBA-15 se sintetizaron con el fin de preparar composites de poliindol. Los materiales mesoporosos de sílice se prepararon mediante el método sol- gel y la aluminación post-síntesis, y se analizaron mediante diferentes métodos (XRD, BET, TEM, y FTIR). Los composites poliindol/hospedaje se prepararon mediante polimerización oxidativa in situ de indol pre-adsorbido, empleando FeCl3 como oxidante. Para caracterizar los distintos composites se utilizaron diferentes métodos TG, FTIR, BET, DRX, SEM y TEM. Estos estudios muestran que después de la polimerización, las estructuras porosas de los materiales se conservan y el poliindol se encuentra dentro de los canales porosos. Los composites presentan una conductividad eléctrica en el rango de 8.7 10-4 y 1.4 10-8 S.cm-1Item Preparation and characterization of activated CMK-1 with Zn and Ni species applied in hydrogen storage(Wiley Online Library, 2015) Juárez, Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar AlfredoThe aim of this work is to prepare CMK-1 modified with Zn and Ni in order to improve its capacity in hydrogen stor- age. The approach that we have followed includes synthesis of nanostructures with the experimental study of its ad- sorption capacity and storage properties. We have shown that CMK-1 ordered porous carbon modified with metals is a promising material for hydrogen storage. The incorporation of metals was performed by wetness impregnation. The samples were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron micro- scope, transmission electron microscopy, X-ray photoelectron spectroscopy, and Brunauer–Emmett–Teller methods. The CMK 1 modified with Zn showed the highest H2 uptake at 77 K and at low and high pressure (1.5 and 4.4 wt.% at 1 and 10 bar, respectively). The introduction of Ni into CMK-1 does not increase hydrogen storage capacity at low pres- sure. However, at a higher pressure (10 bars), Ni-CMK-1 displays improved results in hydrogen uptake compared with those of CMK-1 pristine, 2.4 and 2.1 wt.%, respectively.. Copyright © 2015 John Wiley & Sons, Ltd.Item Synthesis and characterization of Pt-CMK-3 hybrid nanocomposite for hydrogen storage(Wiley Online Library, 2015) Juárez, Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar AlfredoThe nanometric carbon CMK-3 modified with Pt was synthesized and applied as a reservoir for hydrogen uptake. We found that the newly synthesized hybrid composites exhibited significantly enhanced H2 storage. The approach that we have followed includes synthesis of nanostructures with the experimental study of its adsorption capacity and storage properties. In summary, we have shown that CMK-3 ordered porous carbon modified with Pt nanoclusters is a promising material for hydrogen uptake. The samples were characterized by X-ray diffraction, N2 isotherms, X-ray photoelectron spectra and transmission electron microscopy. The nanoparticles of Pt (~1.7 nm) incorporated onto the nanostructured carbon CMK- 3 showed higher hydrogen uptake at low and high pressures (3.3 wt% of H2 sorption at 10 bar and 77 K) than CMK-3.Item Preparation, charactrization and mathematical modeling of keterolac reléase conteined in LP-SBA-15 host.(Universidad Tecnológica Nacional Regional Córdoba., 2017) Cussa , Jorgelina; Juárez , Juliana María; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Juárez , Juliana MaríaDrug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the LP-SBA-15 nanomaterial as a promising new host for drug delivery systems because of its high biocompatibility, in vivo biodegradability, and low toxicity. Ketorolac-LP-SBA-15 was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release, achieving the required therapeutic efficacy. The host shows ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, being the Ritger-Peppas model followed by the Weibull model the best ones. In this work, we show a promising drug storage material for effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. Studies indicate that KETO was adsorbed on the channel surface of LP-SBA-15 without affecting the structure or chemical composition of KETO. Controlled drug delivery systems can achieve precise delivery at the time and place of destination, keeping the concentration of the drug at points in the body within the optimal range and below the toxicity threshold. The study also demonstrates the storage capacity and release properties of LP SBA-15 containing KETO. The release of KETO contained in LP-SBA-15 can offer a significant improvement in the controlled release of the drug and the analgesic and anti-inflammatory effects, positively influenced, by the links formed between the host and drug molecules and by diffusion through the host porosity. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response.Item KETO/LP-SBA-15 Composite as a drug release system.(Universidad Tecnológica Nacional Regional Córdoba., 2017) Cussa , Jorgelina; Juárez , Juliana María; Prados, Antonela; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Juárez , Juliana MaríaControlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. SBA-15 with larger pore sizes material (LP-SBA-15) is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Large pore mesoporous silica supports has been applied in studies of ketorolac tromethamine (KETO) adsorption and release. KETO/LP-SBA-15 composite was synthesized. The material synthesis and loading of KETO into LP-SBA-15 pores were successful. We obtained promising results for controlled drug release using the novel LP-SBA-15 material. The ability of KETO/LP-SBA-15 release was measured. The concentration of KETO in HCl solution or buffer in a specific time was determined by UV-Vis. First-order, Higuchi and Ritger-Peppas (or Korsmeyer-Peppas) models were used to fit experimental release data. Figure 1 show the fitting results, where Qt/Q? is the release fraction per unit mass in time t, k represents release rate in all models and n is a measure of desorption intensity in Ritger-Peppas regression. In this work, we have shown a promising drug storage material for the effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. KETO was adsorbed into LP-SBA-15 channel surface without affecting the chemical structure or composition of KETO. The study also demonstrates the storage capacity and release properties of LP-SBA-15 containing KETO. The release of KETO contained in LP-SBA-15 can offer significant improve in controlled drug release and enhance a good analgesia effect.Item Ketorolac-trometamina/mcf: aplicación en sistemas de liberación de fármacos.(Universidad Tecnológica Nacional Regional Córdoba., 2018) Cussa , jorgelina; Juárez , Juliana María; Prados, Antonela; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Juárez , Juliana MaríaEn los últimos años, la atención se ha dirigido significativamente a la nanociencia y la nanotecnología. La administración de fármacos basados en nanomateriales se ha puesto en relieve por los investigadores académicos e industriales. Diversos materiales nanoestructurados se produjeron y se aplican a la administración de fármacos tales como nanopartículas, nanocápsulas, nanotubos, micelas, microemulsiones y liposomas (Wu et al., 2011). Los sistemas de liberación controlada de fármacos pueden lograr la entrega espacial y temporal precisa de agentes terapéuticos al sitio de destino. Generalmente, los sistemas de administración de fármacos controlada pueden mantener la concentración de fármacos en los sitios precisos del cuerpo dentro de la gama óptima y bajo el umbral de toxicidad, mejorar la eficacia terapéutica y reducir la toxicidad (Wang, 2009). Un sistema de administración de fármacos se puede definir como un sistema capaz de liberar un agente bioactivo portador en una ubicación específica a una velocidad específica. El objetivo principal de este tipo de sistema es la de facilitar la dosificación y la duración del efecto del fármaco, minimizando el daño al paciente y mejorar la salud humana, ya que permiten la reducción de la frecuencia de la dosis (Wang, 2009).Item Composite MCF/KETO. Aplicación en sistemas de liberación de fármacos.(Universidad Tecnológica Nacional Regional Córdoba., 2019) Cussa , jorgelina; Juárez , Juliana María; Prados, Antonela; Gómez Costa, Marcos Bruno; Juárez , Juliana MaríaLa espuma celular mesoestructurada (MCF) es un prometedor material para los sistemas de administración de fármacos dado a la alta biocompatibilidad, biodegradabilidad y baja toxicidad. Sus propiedades incluyen una gran área superficial, poro grande uniforme. En este trabajo, MCF como material de almacenamiento de drogas fue sintetizado con éxito y cargado con la droga ketorolaco-trometamina, obteniendo el composite MCF/ KETO. La síntesis del material y el proceso de carga de ketorolaco-trometamina en los poros de la MCF fueron exitosos tal como se muestra en los análisis de XRD, FTIR, TGA, TEM y texturales. Hemos obtenido resultados prometedores para la liberación controlada de fármacos utilizando el noble material MCF. La aplicación de estos materiales en la liberación de KETO es innovadora, logrando una alta tasa de liberación inicial y manteniendo una tasa constante en los tiempos altos.Item LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release.(Universidad Tecnológica Nacional Regional Córdoba., 2023) Cussa, Jorgelina; Juárez , Juliana María; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Juárez , Juliana MaríaDrug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the nanomaterial LP-SBA-15 as an attractive new host for drug delivery systems due to its high biocompatibility, in vivo biodegradability, and low toxicity. LP-SBA-15/Ketorolac was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release and achieving the required therapeutic efficacy. The host shows the ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release from the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, the Ritger-Peppas model followed by the Weibull model the best ones. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid responseItem Novel preparation of CMK-3 nanostructured material modified with titania applied in hydrogen uptake and storage.(Universidad Tecnológica Nacional., 2017) Juárez , Juliana María; Ledesma , Brenda Cecilia; Gómez Costa, Marcos Bruno; Beltramone , Andrea Raquel; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Beltramone , Andrea Raquel; Ledesma , Brenda CeciliaThis work deals with the development of a novel procedure to synthesize titania-modified nano structured carbon employing Ti-SBA-15 as hard template. The new mesoporous carbon displays high specific surface area of 1044 m2/g and large pore volume of 0.7 cm3/g. XRD pattern of Ti-CMK-3 indicates that the ordered structure of this material is similar to the CMK-3. XRD, XPS and UVeVis-DRS analysis indicated that Ti is highly dispersed as anatase phase in Ti-CMK-3. The synthesized Ti-CMK-3 exhibited significantly enhanced H2 storage properties (2.6 wt%, equivalent to 13 mmol/g) compared with CMK-3 without Ti (2.2 wt%, 11 mmol/g) at 77 K and 10 bar.Item Vanadium and titanium oxide supported on mesoporous CMK-3 asnew catalysts for oxidative desulfurization.(Universidad Tecnológica Nacional., 2016) Rivoira , Lorena Paola; Juárez , Juliana María; Falcón , Horacio; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo; Beltramone , Andrea Raquel; Beltramone , Andrea Raquel; Anunziata , Oscar Alfredo; Juárez , Juliana MaríaVanadium supported-CMK-3 catalysts with vanadium loading of 1–7 wt.% were studied in the oxidative desulfurization (ODS) of dibenzothiophene as a model sulfur compound. The activity was compared with titanium supported-CMK-3. Structural and textural characterization of the catalysts was performed by means of N2 adsorption, XRD, UV–vis–DRS, Raman spectroscopy, XPS, TEM and TPR. The dispersion and the nature of the vanadium species depend on the V loading, so does the catalyst activity. Vanadium supported-CMK-3 with 7 wt.% of vanadium loading was the most active catalyst for ODS of DBT using hydrogen peroxide (H2O2) as oxidant and acetonitrile as solvent. 100% of DBT elimination was attained at short time in mild conditions. Carbon ordered mesoporous CMK-3 with high surface area and high pore volume promotes a very good anchorage of metallic oxides in the carbons framework reaching high active sites distribution and more stable nanoclusters. The reusability of the catalyst indicates that V-CMK-3 is a potential catalyst for the ODS of dibenzothiophene.