Desarrollo, Producción e Innovación en la Investigación científica
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Item H2 storage using Zr-CMK-3 developed by a new synthesis method.(Univesidsad Tecnológica Nacional, 2021) Juárez , Juliana María; Venosta , Lisandro; Anunziata, Oscar Alfredo; Gómez Costa , Marcos Bruno; Anunziata, Oscar AlfredoOne of the biggest problems in using hydrogen as an alternative fuel is that its storage must be safe and portable. This work addresses a new direct synthesis technique used to obtain a novel mesoporous carbon (CMK-3) modified with zirconium oxide. This novel material shows promise for hydrogen adsorption and storage application for energy harvesting. Zirconium oxide (Zr-CMK-3) material is achieved through successful synthesis and characterized by XRD, SEM,Raman, BET, UV-Vis-DRS, XPS and TEM analyses. Zr-CMK-3 signifi- cantly improved H2 storage performance (reaching at 77 K and 10 bar 4.6 wt%) comparedto the pristine CMK-3. The novel material is favorable for H2 uptake by using weak bonding (physisorption). A hydrogen uptake mechanistic approach is proposed and the role of the Zr+4 cation in hydrogen adsorption is discussed.Item LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release.(Univesidsad Tecnológica Nacional, 2023) Cussa, jorgelina; Juárez , Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar AlfredoDrug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the nanomaterial LP-SBA-15 as an attractive new host for drug delivery systems due to its high biocompatibility, in vivo biodegradability, and low toxicity. LP-SBA-15/Ketorolac was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release and achieving the required therapeutic efficacy. The host shows the ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release from the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, the Ritger-Peppas model followed by the Weibull model the best ones. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response.Item HaP/SBA-3 Nanostructured Composite to Remove Fluoride Effectively from Contaminated Water.(Univesidsad Tecnológica Nacional, 2021) Cussa, Jorgelina; López , Claudia; Anunziata, Oscar Alfredo; Anunziata, Oscar AlfredoHighly ordered pore mesoporous silica composites, like SBA-3 and hydroxyapatite (HaP) nanocrystals, characterized by X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and textural properties, were successfully applied to remove fluoride from contaminated water. The proposed procedure to prepare HaP/SBA-3 wassuccessful, which acts as supports to anchor the HaP crystals, in nanometer-scale (<2nm), with higher fluoride retention from contaminated water. The free OH- groups of HaP nanocrystals, within the host, facilitated the high-performance fluoride trapping. The fluoride retention activity was much higher than that of pure HaP and the composites HaP/SBA-15 and HaP/MCM-41.Item Optimization of the synthesis of SBA-3 mesoporous materials by experimental design(Elsevier Inc., 2016-02-18) Ponte, María Virignia; Rivoira, Lorena Paola; Cussa, Jorgelina; Martínez, Maria Laura; Beltramone, Andrea Raquel; Anunziata, Oscar AlfredoSBA-3 mesoporous materials are characterized by hexagonal regular arrangements of channels with diameters >2 nm, high specific surface areas and high specific pore volumes. In the work reported herein, experimental design-response surface methodology (RSM) is used to model and optimize the synthesis conditions for SBA-3 mesoporous materials. In this study, we evaluate the influences of surfactant/silica source molar ratios, aging times, temperature and pH on the synthesis of SBA-3 mesoporous materials by analyzing the XRD intensities pertaining to the [100] signal. Response surfaces were obtained using the BoxeBehnken design, and the combination of reaction parameters was optimized. By applying statistical methodology, higher levels of the objective function (XRD intensities pertaining to the [100] signal) were obtained using cetyltrimethylammonium bromide (CTAB)/tetraethyl orthosilicate (TEOS) molar ratios of 0.07 and 0.16, HCl/TEOS molar ratios of 8 and 11, reaction temperatures of 35 and 45 ◦C and aging times of 12e24 h. The mesoporous SBA-3 samples obtained were characterized using small-angle X-ray powder diffraction (XRD), BET, FTIR and 29Si NMR-MAS, scanning electron microscopy (SEM) and transmission electron microscopy (TEM).Item Controlled drug release system: cyclophosphamide delivery contained in LP-SBA-15 functionalized with tertbutylamine.(Univesidsad Tecnológica Nacional, 2023) Cussa, Jorgelina; Juárez , Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo; Anunziata, Oscar Alfredo; Juárez , Juliana MaríaControlled drug administration systems can keep the level of drugs in specific locations in the organism with low toxicity and above the optimal level. We suggest the LP-SBA15 material as a auspicious new host for drug delivery systems because of its low toxicity high biocompatibility and in vivo biodegradability. LP-SBA-15 materials were synthesized and functionalized using 0-15-30% of tert-butylamine (TBA) and used as effective drug delivery systems. The anticancer drug Cyclophosphamide (CP) is an alkylating compound which is a phosphoramide derivative and is habitually used in autoimmune diseases. Reactive oxygen species production has been related to the mechanism of CP-induced cell death or tumor cell killing. The activated metabolites of CP are released in both healthy and tumor tissues and destroy the cellular DNA and proteins as well as mitochondrial and lysosomal membranes. CP was loaded into the nanomaterial of the transporters and characterized by XRD, FTIR, TGA, TEM and texture, determining the adsorption capacity and its release. The release of the drug was studied for each material by simulating the physiological conditions and submerging the composite, at 37 °C with constant stirring, in a HCl solution (0.1 M) for the first two hours and in Buffer solution pH = 7 the following hours to simulate the conditions of the organism. Release experiment were conducted to determine the requisite efficacy of treatment. The study was performed by UV-Vis spectrophotometry to evaluate the amount of CP released. The mechanism of drug release from the LP-SBA-15 matrix was evaluated by adjusting the experimental data, being the Ritger-Peppas. The promising results we obtained for the controlled release of the drug in a controlled manner using the new material, reaching a quick initial release rate and maintaining a constant rate at high moments, allow us to keep the concentration of the drug in the therapeutic efficacy range, applying it to a great extent to the treatment of diseases that require a rapid response. Lastly, it was suggested that the LP-SBA-15 nanomaterial functionalized with 15% TBA was the most desirable system due to they had adequate amounts of both drug loading and release.Item Nanostructured ketorolac-tromethamine/MCF: synthesis, characterization and application in drug release system(Current Nanoscience, 2018) Juárez, Juliana María; Cussa, Jorgeliba; Gómez Costa, Marcos Bruno; Anunziata, Oscar AlfredoControlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured cellular foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity.Item The humanization of chemical species. "Path to the hidden reality".(Univesidsad Tecnológica Nacional, 2023) Anunziata, Oscar AlfredoThis work is multidisciplinary and brings together aspects of Quantum Physic chemistry, Physics, Chemistry and Epistemology/Semiotics. By exploring topics ranging from materials to design, it alsoseeks to elucidate the underlying connections between the natural (visible reality) and the artificial (hidden reality), and experiment and modeling. The results are intended to contain elements of discovery and surprise that often accompany the gainingof new knowledge toward a new conception of the architecture and function of the mass of matter and energy that sustains our thoughts. We conceive of Reality as everything that is detected by our senses, and especially that which is visible to our eyes, or which, aided by the development of high-tech equipment, we can detect. Nevertheless, isthis reality the only one? This conception does not explain phenomena that occur in the Cosmological Nature, so my proposal is that other "Hidden" realities exist but we do not detect them, or that they simply do not exist. After "humanizing" (giving the attribution of thinking, responding, acting), to species that we do not conceive to have "Life" such as atoms, to cite one, every particle that makes up the mass of matter andenergy of the Universe led me to the "creation of a New chemical species" (C-Zr-SO4H2), recently reported1 . This attribution ascribed to mass/energetic species, without neural systems, led me after three years toconceive the Idea of Hidden Reality and to generate a possible mechanism (architecture), of how we think when our objective is to hit an “invisible target”, or to "create" new targets. Abstraction. The symbolic abstraction (inscrutable variables). Abstract Symbolism (parameterization of abstract variables). Symbolic Reality (expression of mass of matter or energy indefinite, but symbolized).Real Symbolism (parameterization of functional variables that replicate the Hidden Reality). From HiddenReality to Detectable Reality.Item SYNTHESIS OF g-C3N4/METAL-SBA-15 COMPOSITE: STUDY OF THE INFLUENCE OF THE DIFFERENT METALS ANCHORED IN THE SUPPORT.(Univesidsad Tecnológica Nacional, 2023) Martínez , María Laura; Parreño Romero , Miriam; Anunziata, Oscar Alfredo; Domine, MarceloCarbon nitride (g-C3N4) polymers have garnered considerable attention from the environmental and energy sectors due to their low cost, low toxicity, unique structural and physicochemical properties, and their high physical and chemical stability; they find application as catalysts, as electrodes, as optoelectronic materials, etc. These materials primarily composed of carbon and nitrogen can be synthesized using various methods, but thermal polymerization employing low-cost raw materials containing carbon and nitrogen predominates. This study synthesized g-C3N4 supported Metal-SBA-15 mesoporous materials by evaluating the effect of metal on g-C3N4 formation. Carbon nitrides were synthesized using urea through the thermal polymerization method. Various supported carbon nitrides on mesoporous materials from the Si-based SBA-15 family were prepared. Additionally, a series of materials containing Ga, Al, Sn, and Zr anchored on SBA-15 (with Si/Metal ratio of 20) were tested. The attained g-C3N4/Metal-SBA-15 composites were characterized by XRD, ICP, EA, HR-TEM, SEM-EDX, and N2 adsorption isotherms, among others. To explore the chemical structure of the composites, the chemical bonds existing within the g-C3N4 structure were investigated by FT-IR spectroscopy. The FT-IR spectra of g-C3N4 samples, displayed characteristic peaks at 810 cm-1, 1410 cm-1, 1645 cm-1, and 3100– 3300 cm-1, which describe bending modes characteristic of the out-of-plane tri-units of triazine and C=N, stretching vibrations typical of the C=N and C–N bonds of aromatic CN heterocycles, and the stretching mode of the N‒H bond of non-condensed terminal amino groups, respectively. While SBA-15 material without metal did not exhibit absorption bands characteristic of a g-C3N4, Ga-SBA-15 and Zr-SBA-15 materials exhibited weak absorption bands in the region of 1100 and 1700 cm-1. Interestingly, materials containing aluminum and tin not only exhibited the characteristic bands of SBA-15 but also added the typical bands of g-C3N4. These results, also confirmed by other analysis, revealed that the g-C3N4 chemical structure was efficiently supported onto the metal-containing mesoporous materials. To complete the study, carbon nitride materials were attempted to be synthesized with sulfated zirconia/SBA-15 at different Si/Metal ratios. The results obtained were promising, thus allowing proving the positive effect of S species on the g-C3N4 formation.Item LP-SBA-15, functionalized with tert-butylamine a novel controlled release system for cyclophosphamide.(Univesidsad Tecnológica Nacional, 2013) Juárez , Juliana María; Cussa, Jorgelina; Gómez costa , Marcos Bruno; Anunziata, Oscar Alfredo; Anunziata, Oscar AlfredoControlled drug administration systems can keep the level of drugs in specific locations in the organism with low toxicity and above the optimal level. We suggest the LP-SBA-15 material as an auspicious new host for drug delivery systems because of its low toxicity high biocompatibility and in vivo biodegradability. LP SBA-15 materials were synthesized and functionalized using 0-15-30% of tert butylamine (TBA) and used as effective drug delivery systems. The anticancer drug Cyclophosphamide (CP) is an alkylating compound which is a phosphoramide derivative and is habitually used in autoimmune diseases. Reactive oxygen species production has been related to the mechanism of CP-induced cell death or tumor cell killing. The activated metabolites of CP are released in both healthy and tumor tissues and destroy the cellular DNA and proteins as well as mitochondrial and lysosomal membranes. CP was loaded into the nanomaterial of the transporters and characterized by XRD, FTIR, TGA, TEM and texture, determining the adsorption capacity and its release. The release of the drug was studied for each material by simulating the physiological conditions and submerging the composite, at 37 °C with constant stirring, in a HCl solution (0.1 M) for the first two hours and in Buffer solution pH = 7 the following hours to simulate the conditions of the organism. Release experiment were conducted to determine the requisite efficacy of treatment. The study was performed by UV-Vis spectrophotometry to evaluate the amount of CP released. The mechanism of drug release from the LP-SBA-15 matrix was evaluated by adjusting the experimental data, being the Ritger-Peppas (figure 1) The promising results we obtained for the controlled release of the drug in a controlled manner using the new material, reaching a quick initial release rate and maintaining a constant rate at high moments, allow us to keep the concentration of the drug in the therapeutic efficacy range, applying it to a great extent to the treatment of diseases that require a rapid response. Lastly, it was suggested that the LP-SBA-15 nanomaterial functionalized with 15% TBA was the most desirable system due to they had adequate amounts of both drug loading and releaseItem Large pore SBA-15 functionalized as drug carrier of Cyclophosphamide.(Univesidsad Tecnológica Nacional, 2023) Juárez , Juliana María; Cussa, Jorgelina; Anunziata, Oscar Alfredo; Gómez Costa, Marcos BrunoControlled drug administration systems can keep the level of drugs in specific locations in the organism with low toxicity and above the optimal level. We suggest the LP-SBA-15 material as an auspicious new host for drug delivery systems because of its low toxicity high biocompatibility and in vivo biodegradability. LP-SBA-15 materials were synthesized and functionalized using 0-15-30% of tert-butylamine (TBA) and used as effective drug delivery systems. The anticancer drug Cyclophosphamide (CP) is an alkylating compound which is a phosphoramide derivative and is habitually used in autoimmune diseases. Reactive oxygen species production has been related to the mechanism of CP-induced cell death or tumor cell killing. The activated metabolites of CP are released in both healthy and tumor tissues and destroy the cellular DNA and proteins as well as mitochondrial and lysosomal membranes. CP was loaded into the nanomaterial of the transporters and characterized by N2 adsorption-desorption, Ultraviolet-visible diffusereflectance spectroscopy (UV-Vis DRS), FTIR, determining the adsorption capacity and its release. The release of the drug was studied for each material by simulating the physiological conditions and submerging the composite, at 37 °C with constant stirring, in a HCl solution (0.1 M) for the first two hours and in Buffer solution pH = 7 the following hours to simulate the conditions of the organism. Release experiments were conducted to determine the requisite efficacy of treatment. The study was performed by UV-Vis spectrophotometry to evaluate the amount of CP released. The mechanism of drug release from the LP-SBA-15 functionalized matrix was evaluated by adjusting the experimental data, being the Ritger-Peppas model, Weibull model and First-Order model, the best models to adjust the experimental data is the, which is confirmed by the R2 coefficient of determination. The promising results we obtained for the controlled release of the drug in a controlled manner using the new material, reaching a quick initial release rate and maintaining a constant rate at high moments, allow us to keep the concentration of the drug in the therapeutic efficacy range, applying itto a great extent to the treatment of diseases that require a rapid response. Lastly, it was suggested thatthe LP SBA-15 nanomaterial functionalized with 15% TBA was the most desirable system due to they had adequate amounts of both drug loading and release